With toluene a 39% yield was obtained, whereas with the usage of other cosolvents like water or THF either deprotection of the TBS group or no conversion was observed. Significant yield improvements and minimization of the reaction time (7 days to 3 h) could be achieved with the assistance ...
Heats of solution in toluene were measured followed by heats of reaction with HCl, I2, C6F5OH, C6H5OH, CF3CH2OH, or t-BuOH in toluene. Derived D(M-X) values decrease in the order OH ≈Cl > alkoxide ≈ NH2 > phenoxide > I ≈ H > aryl > Me > alkyl, metallacyclopentane > η...
Acid chlorides can be used to make new compounds for example acetophenone. Answer and Explanation: - an amide plus HCl The mechanism for the reaction between an amine and and acid chloride is given below. Step 1: Nucleophilic ...
A method of quantitative determination ofsulphanilamideby reaction with p-dimethylaminocinnamic aldehyde [48] in acid medium has been suggested. Prasad et al [53] determinedsulphanilamide, sulphapyridine, sulphaguanidine, sulphathiazole, sulphamerazine and sulphadiazine by titration with KBr[O.sub.3...
Activation of the carboxylic acid can easily be accomplished by the classicalthionyl chloridemethod.13,14To generate acid chlorides under mild conditions without the evolution of gaseous HCl the reaction is carried out in SOCl2/DMF15or started with the dicyclohexylammonium salt of the carboxylic acid...
The absolute configurations of the standard amino-acid residues in 2 were determined using the Marfey's method.9 Compound 2 was subjected to complete acid hydrolysis (6 N HCl, 110 °C for 16 h), followed by reaction with FDAA (Nα-(5-fluoro-2,4-dinitrophenyl)-L-alaninamide) Figure 1...
The reaction was terminated after stirring the solution for 12 h at room tem- perature, then the organic phase solution was washed with HCl (3M). The solid sodium bicarbonate was then slowly added to the organic phase to react with the HCl away. The solution was stirred vigorously until ...
To further confirm the structure of the compound obtained, an alternative synthetic route was carried out from unsubstituted thiazolidine–triazole hybrids 24–30 by Knoevenagel reaction with aromatic aldehydes (Method K) under milder conditions: ethanol with piperidine as the catalyst [29]. This metho...
The reactions of potassium phthalimide with Grignard reagents which give 3-hydroxy-3-alkylphthalimidine or 3-alkylidenephthalimidine, are described. The formations of the two products are controlled by treatment of the reaction mixture either with aq. NH4Cl-NH3 or with aq.HCl. The structures of...
1.Oxidized wax is modified by amidation reaction to produce acylamide with better physical and chemical properties.氧化蜡经过胺改性可以得到具有更佳物化性能的脂肪酸酰胺。 2.By combining 2 chloropyridine, 1,3,4 thiadiazole and acylamide, three toxophoric moieties seven 2 [ N (1 methoxycarbonyl)ethy...