Platinum was anchored by coordination and methotrexate by amide bonds. In all cases, drug incorporation in the molecule was assessed to be 100%. NMR was used for methotrexate conjugate analysis, while platinum incorporation was evaluated by CHN analysis. The in vitro antiproliferative activity against...
nylon polyamide), in drugs (e.g.β-lactam antibiotics), inpeptides and proteinshas stimulated research leading to safe, simple, and in the case of α-asymmetriccarboxylic acidsnearly racemization-free, condensation methods.
The preparation of amides is one of the most common reactions inorganic synthesisand a key reaction for the preparation of peptide drugs and nucleic acid drugs in recent years. The reaction for synthesizing amide bonds is very extensive in the laboratory, and there are currently many types ...
The development of multidrug resistance (MDR) has reduced the effectiveness of β-lactams as antimicrobial drugs [5,23]. The main reason for β-lactam resistance is the production of β-lactamase; consequently, the development of β-lactamase inhibitors has been one of the main strategies in ...
In previous paper [1], we reported that the conjugates of monomethoxy-poly(ethylene glycol) (MeO-PEG) bound to 5-fluorouracil (5FU) via urethane or urea bonds showed remarkable survival effects against p388 lymphocytic leukemia in ... T Ouchi,Hidetoshi Kuroda,Yuichi Ohya 被引量: 73发表: ...
Analysis of the 1H–1H COSY spectrum gave the two partial structures I (C-1 to NH) and II (C-3 to C-13) drawn as the bold lines in Figure 2. Regarding the stereo- chemistry of the conjugated double bonds in II, the coupling constants of 9-H (14.0 Hz), 10-H (14.0 Hz), 11...
It is commonly used as a strong base in organic synthesis, offering a versatile platform for deprotonation reactions and the formation of carbon-nitrogen bonds. Lithium amide is also utilized in the production of lithium batteries, as it serves as a precursor for the synthesis of lithium nitride...
mouse LD50 intravenous > 1gm/kg (1000mg/kg) Drugs in Japan Vol. 6, Pg. 819, 1982. View all 5. MSDS2.Hazard identification 2.1 Classification of the substance or mixture Acute toxicity - Oral, Category 4 Acute toxicity - Dermal, Category 4 Acute toxicity - Inhalation, Category 4 Carcin...
Sodium diformylamide is also used as a catalyst in certain organic transformations, facilitating the formation of carbon-carbon bonds. Additionally, it has been studied for its potential use in medicinal chemistry, showing promising results in the development of new drugs. Overall, Sodium diformyl...
The term stereochemically isomeric forms of compounds of the present invention, as used hereinbefore, defines all possible compounds made up of the same atoms bonded by the same sequence of bonds but having different three-dimensional structures which are not interchangeable, which the compounds of ...