Recently, a phase Ib, first-in-human (FIH) study in healthy and HF subjects (ClinicalTrials.gov identi- fier: NCT03276728) reported that AMG 986 exposure increases non-linearly with increasing oral doses of 5 mg to 650 mg [3]. The oral bioavailability of AMG 986 ranges Vol....
Indeed, adagrasib was granted accelerated approval by the US FDA on December 12, 2022.19 Approval was based on KRYSTAL-1, a multicenter, single-arm, open-label clinical trial (NCT03785249), which included patients with locally advanced or metastatic NSCLC with KRAS G12C mutations. Efficacy was...
Indeed, adagrasib was granted accelerated approval by the US FDA on December 12, 2022.19 Approval was based on KRYSTAL-1, a multicenter, single-arm, open-label clinical trial (NCT03785249), which included patients with locally advanced or metastatic NSCLC with KRAS G12C mutations. Efficacy was...
Etelcalcetide (AMG 416), a novel peptide agonist of the calcium-sensing receptor, reduces PTH levels in subtotal nephrectomized (Nx) rats and in hemodialysis patients with secondary hyperparathyroidism (SHPT) in clinical studies; however, effects of etelcalcetide on bone have not been determined....
允许对照组交叉以减少患者脱落（同时在方案修订3中修订了统计假设，初始α更多在PFS，样本量从650例修订...