Introduction: Thrombopoietin (TPO) is a key regulator of hematopoiesis, and its effects are mediated through the binding and intracellular signaling of the thrombopoietin receptor (cMpl), a member of the cytokine receptor superfamily. Studies of knockout mice lacking expression of TPO or cMpl reveal...
(SEQ ID NO: 24), a Env element (SEQ ID NO: 23), a cPPT (SEQ ID NO: 26), a H1 promoter (SEQ ID NO: 27), a shRNA targeting PARP1 (shPARP1. (SEQ ID NOS: 6-10), a Woodchuck Post-Transcriptional Regulator), Element (WPRE) (SEQ ID NO: 30), and a 3′ LTR delta U3 ...
The invention further relates to use of this enhancer element for regulated gene expression and for drum screening. BACKGROUND OF THE INVENTION The β3 -adrenergic receptor (β3 -AR) is an important regulator of metabolic activity in brown and white adipose tissue, two major sites for ...
The sensitivity of the commonly used progressive multiple sequence alignment method has been greatly improved for the alignment of divergent protein sequen... DA Benson,MS Boguski,DJ Lipman,... 被引量: 1183发表: 1994年 Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, ...
Adenosine: an endogenous regulator of innate immunity. Trends Immunol. 2004;25(1):33–9. PubMed Google Scholar Barletta KE, Ley K, Mehrad B. Regulation of neutrophil function by adenosine. Arterioscler Thromb Vasc Biol. 2012;32(4):856–64. CAS PubMed PubMed Central Google Scholar Wang ...
Genes, RegulatorTranscription, GeneticGene Expression RegulationCyclic AMPTransduction, GeneticCONTEXT AND OBJECTIVE: Many uncertainties concerning risk factors and evolution of cognitive disorders remain. We describe the methods and preliminary results from the investigation of the cognitive function in the ...
The relationship of apolipoprotein-B genotype (Lpb) to diet-induced hypercholesterolemia and atherosclerosis was studied in von Willebrand disease (vWD) an... TC Nichols,DA Bellinger,KE Davis,... 被引量: 0发表: 2018年 miR-141 as a regulator of the mitochondrial phosphate carrier (Slc25a3) in...
Strain TX07-7308 mutator family transposase was associated with genes encoding a putative chitinase (F7308_0017, 942 aa) and a two-component response regulator (F7308_0016, 239 aa) whose orthologs were present in strain ATCC 25015, but not in strain ATCC 25017 and all other publicly ...
Predominant molecular functions of genes methylated in MCL included transcription factor/regulator activity and DNA binding (Supporting Information Table IVS). Notably, nine of the transcription regulators methylated in MCL were homeobox transcription factors (DLX2, HLXB9, HOXA2, HOXA9, HOXA13, LHX1,...
Companies of Johnson & Johnson announced the primary results from the Phase 1/2 study evaluating the investigational gene therapy botaretigene sparoparvovec in patients with the inherited retinal disease X-linked retinitis pigmentosa associated with...