单细胞转录组测序数据的可变剪接(alternative splicing)分析方法总结 可变剪接(alternative splicing),在真核生物中是一种非常基本的生物学事件。即基因转录后,先产生初始RNA或称作RNA前体,然后再通过可变剪接方式,选择性的把不同的外显子进行重连,从而产生不同的剪接异构体(isoform)。这种方式,使得一个基因可产生多个不...
Alternative splicing analysis provides insight into the domestication and improvement of pear (Pyrus pyrifolia) fruitAlternative splicingPearDomesticationImprovementFruit traitsAlternative splicing (AS) plays a vital role in response to environmental stress. However, the functional impacts of AS on fruit ...
可变剪接(alternative splicing),在真核生物中是一种非常基本的生物学事件。即基因转录后,先产生初始RNA或称作RNA前体,然后再通过可变剪接方式,选择性的把不同的外显子进行重连,从而产生不同的剪接异构体(isoform)。这种方式,使得一个基因可产生多个不同的转录本,这些转录本分别在细胞/个体分化发育的不同阶段,在不...
3.8. Transcriptome-wide alternative splicing analysis in disease Aberrant splicing greatly contributes to the pathologies of many diseases as mentioned. Indeed, the detection of differential splicing not only serves as predictive, diagnostic, or prognostic biomarkers but also stratifies patients with differe...
Molecular cloning and alternative splicing analysis of hepatoma associated gene HTA To obtain the full length cDNA sequences of hepatoma associated gene HTA, analyze its alternative splicing, detect the expression pattern of 2 HTA gene tra... Y Liu,Y Zhao,S Fang,... - 《Journal of Central So...
Analysis of alternative splicing in vivo using minigenes. in: Westhof E, Bindereif A, Scho¨ n A, Hartmann K (eds). Handbook of RNA Biochemistry, vol. 2 Wiley-VCH: Weinheim, 2004, pp 755-782.Tang, Y., Novoyatleva, T., Benderska, N., Kishore, S., Thanaraj, T. A., Stamm,...
A survey of computational methods in transcriptome-wide alternative splicing analysis (2015) A survey of computational methods in transcriptome-wide alternative splicing analysis. Biomol. Concepts, 6, 59-66.Wang J, Ye Z, Huang TH, Shi... J Wang,Z Ye,HM Huang,... - 《Biomol Concepts》 被...
我有一段内含子要进行分析，进入EBI的Intron analysis,里面要输入“Type in 5' flanking exonic terminal...
Moreover, it has been demonstrated that the presence of circulating mRNA in blood stream from cancer patients can be associated with the tumor progression25 which could be a promising approach for detecting deregulation of alternative splicing events in a less-invasive analysis. We believe that this...
Alternative splicing is a process that enables a messenger RNA (mRNA) to direct synthesis of different protein variants (isoforms) that may have different cellular functions or properties. It occurs by rearranging the pattern of intron and exon elements that are joined by splicing to alter the mRN...