This prevents a direct comparison between patients with identical total scores. We aim to evaluate how multidimensionality affects the performance of the ALSFRS-R in clinical trials. Methods: We simulated clinical trial data with different treatment effects for the ALSFRS-R total score and its sub...
(ALSFRS-R) to better characterize SVC in clinical decision-making in ALS.Background: No established markers of ALS disease progression exist; however, disability and death commonly result from declining respiratory muscle function, suggesting that respiratory measures should be useful for predicting ...
of the four sub-scores of the revised ALS functional rating scale (ALSFRSr), the forced vital capacity (FVC), and the body mass index (BMI). We... O Juliette,P Pierre-Franois,MSD Sophie - 《Journal of Neurology》 被引量: 0发表: 2023年 加载更多来源...
despite the correlation observed between alsfrs scores and degeneration in pc and ci, our results suggest that this subjective scale is not a good parameter for the evaluation of the structural damage in encephalic portions of the corticospinal tract....
Amyotrophic lateral sclerosis (ALS) patients lack effective treatments to maintain motor and neuromuscular function. This study aimed to evaluate the effect of a home-based exercise program on muscle strength, ALS scores, and transcriptome in ALS patients, Clinical Trials.gov #NCT03201991 (28/06/...
ALSFRS-R scores correlate significantly with quality of life as measured by the Sickness Impact Profile, indicating that the quality of function is a strong determinant of quality of life in ALS.JesseM.CedarbaumandNancyStamblerandErrolMalta
(unadjusted), or for one item: climbing stairs (after Bonferroni correction for multiple comparisons); and (3) delayed worsening of ALSAQ-40 domain scores representing daily living/independence, eating and drinking (unadjusted).#These post-hoc analyses identified the ALSFRS-R item scores and ALSA...
ALSFRS-R scores correlate significantly with quality of life as measured by the Sickness Impact Profile, indicating that the quality of function is a strong determinant of quality of life in ALS.doi:10.1016/S0022-510X(99)00210-5Jesse M. Cedarbaum...
Associations between the ALSFRS‐R score and urate levels during 12?months of edaravone treatment for amyotrophic lateral sclerosis: Post hoc analysis of ALSFRS‐R scores in clinical studies MCI186‐16, MCI186‐17, and MCI186‐19ALSALSFRS‐R...
utility in populations of patients with MND when utility data have not been collected.MethodsDirect mapping models were developed using ordinary least squares and Tobit regression analyses to estimate EQ-5D-5L utilities (based on English tariffs), with ALSFRS-R total, domain, and item scores used...