Inter-evaluator reliability of the ALS functional rating scale. Amyotroph Lateral Scler Other Motor Neuron Disord 2004;5(4):235-9.Miano B, Stoddard G, Davis S, Bromberg M. Inter-evaluator reli- ability of the ALS Functional Rating Scale. Amyotroph Lateral Scler 2004;5:235-239....
Scale bar, 1 mm (e, f); 100 µm (g–k). Source data Full size image Secondary outcome measures The ALS Functional Rating Scale Revised (ALSFRS-R) score is a patient-reported, clinician-assessed, 48-point scale measuring overall functional status. The total score had a variable ...
functional in silico predictions from nine programs, including databases such as SIFT40, PolyPhen2 (ref.41) and Mutation Taster42, and those described in Li et al.43. Additional databases were included that assess the variant tolerance of each gene using the Residual Variation Intolerance Score (...
33% in the mexiletine groups. In conclusion,the results suggest that daily 300 mg mexiletine has no effects on axonal sodium current and ALSFRS-R deterioration in ALS.We have to attempt another trial using a higher dose of mexiletine or other agents to suppress sodium currents and ALS progressi...
While this greatly limits the independent diagnostic value of NfL [169], there is a stronger correlation of NfL level EXPERT OPINION ON DRUG DISCOVERY 457 with the rate of disability progression as measured using the revised ALS Functional Rating Score (ALSFRS-R), a change in the downward ...
main analyses of these data: (1) examine the intra- and inter-patient protein variability in CSF; (2) explore the association of inflammation with rate of disease progression; and (3) develop a mixed-effects model to best explain the decrease in ALS-Functional Rating Scale (ALS-FRS) score...
There were trends toward a slower decline in ALS Functional Rating Scale-Revised (ALSFRS-R) scores, which measure patients’ ability to carry out daily living activities, and a significant slowing in lung function decline, as measured through the forced vital capacity (FVC) parameter....
ALS Functional Improvement:the ALS Functional Rating Scale (ALSFRS-R) is an instrument for evaluating the functional status of patients with ALS and is used to monitor functional change in a patient over time. CNM-Au8 NfL Responders demonstrated: ...
All ALS patients were clinically staged using the amyotrophic lateral sclerosis functional rating score (ALSFRS-R) (Cedarbaum et al., 1999) and ALSFRS-R progression rate, a marker of survival, was measured according to the previously reported formula; (48-ALSFRS-R)/duration of symptoms (Labra ...
primary outcome measure will be death from any cause at 18 months defined from the date of randomisation. Secondary outcome measures will be changes in three functional rating scales, the ALS Functional Rating Scale-Revised, The EuroQOL (EQ-5D), and the Hospital Anxiety and Depression Scale. ...