There were trends toward a slower decline in ALS Functional Rating Scale-Revised (ALSFRS-R) scores, which measure patients’ ability to carry out daily living activities, and a significant slowing in lung function decline, as measured through the forced vital capacity (FVC) parameter....
Recent studies demonstrated already a decline of motor unit index values during disease progression comparable to the ALS functional rating score in a scientific environment where variability was diminished by intense rater training. Our goal was to implement MUNIX as routine procedure in a specialized ...
M. et al. The ALSFRS-R: A revised ALS functional rating scale that incorporates assessments of respiratory function. J. Neurol. Sci. 169, 13–21 (1999). Article CAS PubMed Google Scholar Schalk, G., McFarland, D. J., Hinterberger, T., Birbaumer, N. & Wolpaw, J. R. BCI2000:...
Each question is scored (0–4) and the sum is referred to the patient’s ALS functional rating score60. ALS-FRS is the most widely used outcome measure of disease progression in ALS. The survey is often subjective and the scale is not linear in relation to the severity of functional ...
(single-breath count, read-aloud passage and free speech; Extended Data Fig.2) each correlated highly with the bulbar subdomain of the ALS Functional Rating Scale-Revised (ALSFRS-R; Pearson’sR = 0.8, slope = 1.14; Pearson’sR = 0.89, slope = 0.98; and Pearson’sR ...
Common measures in routine clinical care include limb strength as measured by manual muscle testing or hand-held dynamometry, physical function as measured by the ALS Functional Rating Scale (ALSFRS) and its revised version (ALSFRS-R) [1, 2], and respiratory parameters such as forced vital ...
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[range, 55.5 to 68 years]; 178 men) with ALS symptoms of ≤18 months' duration at 16 ALS clinics throughout the United States. The patients completed a modified Block Food Frequency Questionnaire (FFQ), ALS Functional Rating Scale-Revised (ALSFRS-R), and respiratory function testing using ...
The ALS Functional Rating Scale Revised (ALSFRS-R) score is a patient-reported, clinician-assessed, 48-point scale measuring overall functional status. The total score had a variable range at screening (mean 36, range 29–40), and participants progressed at a mean rate of 1.2 points per mont...
M. et al. The ALSFRS-R: A revised ALS functional rating scale that incorporates assessments of respiratory function. J. Neurol. Sci. 169, 13–21 (1999). Article CAS PubMed Google Scholar Schalk, G., McFarland, D. J., Hinterberger, T., Birbaumer, N. & Wolpaw, J. R. BCI2000:...