Methods: We simulated clinical trial data with different treatment effects for the ALSFRS-R total score and its subscales (i.e. bulbar, fine motor, gross motor and respiratory). We considered scenarios where treatment reduced the rate of ALSFRS-R subscale decline either uniformly (i.e. all ...
(ALSFRS-R) and its progression rate of ALSFRS-R correlation with survival time.Methods:Application of 2000 word Union of Neurology El Escorial diagnostic criteria retrospectively analyzed 64 case of amyotrophic lateral sclerosis clinical date,be ALSFRS-R score and the progress rate(⊿FS)and Kaplan-...
Correlation between total ALSFRS-R score and %predicted SVC was the highest (r=.5519; p<.0001). Percent of SVC variance explained by dyspnea, orthopnea, respiratory insufficiency, and the entire respiratory subdomain was 13%, 10%, 12%, and 18%, respectively. Thirty percent of SVC variance...
DESIGN/METHODS:Serum creatinine at first and subsequent clinic visits was compared with ALSFRS-R total score and ALSFRS-Rw from 2010-2012 in 311 ALS patients [183M;128F; 55.7±12.7(SD)years]. Cross-sectional analysis of all data as well as change in serum creatinine and ALSFRS-Rw between ...
The differences in ALSFRS‐R total score change and urate change were evaluated using the mixed model for repeated measurement for overall population, by urate‐level subgroup, and by trial. Results Compared with the PE group, the EE group showed a slower decline in ALSFRS‐R score, regardless...
There was a marked relationship between patients' weight status and total ALSFRS-R score (r = .43, p < .0001). Decrease in bulbar function score correlated with weight loss (r = .41, p < .0001). Eighteen percent of patients who reported a decrease in both total ALSFRS-R and bulbar ...
The assessment of intra-rater agreement demonstrated no systematic changes between time points; limits of agreement were 4.3 points for the total score and ranged from 1.6 to 2.4 points for the domain scores. Coefficient alpha values were acceptable. Discussion The self-administration version of the...
Methods: We simulated clinical trial data with different treatment effects for the ALSFRS-R total score and its subscales (i.e. bulbar, fine motor, gross motor and respiratory). We considered scenarios where treatment reduced the rate of ALSFRS-R subscale decline either uniformly (i.e. all ...
Correlations between %predicted SVC and individual respiratory ALSFRS-R subdomain items, respiratory subdomain score (maximum score of 12), and total ALSFRS-R score (maximum score of 48) were evaluated using the Pearson correlation coefficient. Pearson's chi-squared test was used to evaluate ...
Bulbar onset, faster disease progression at enrollment, and a lower ALSFRS-R score at baseline were associated with a sudden 5-point or more increase in the ALSFRS-R total score. ALSFRS-R items 2 (saliva), 9 (stairs), 10 (dyspnea), and 11 (orthopnea) were the primary drivers when a ...