-ketoglutarate (AKG), a precursor of glutamate and a critical intermediate in the tricarboxylic acid cycle, shows beneficial effects on intestinal function. ... Shuai,Chen,Peng,... - 《Oncotarget》 被引量: 0发表: 2017年 Effects of α-ketoglutarate on energy status in the intestinal mucosa of...
Alpha-Ketoglutarate and intestinal function作者:Hou, Yongqing*; Wang, Lei; Ding, Binying; Liu, Yulan; Zhu, Huiling; Liu, Jian; Li, Yongtang; Kang, Ping; Yin, Yulong; Wu, Guoyao来源:Frontiers in Bioscience-Landmark, 2011, 16(1): 1186-1196.DOI:10.2741/3783...
Alpha-ketoglutarate (AKG), a precursor of glutamate and a critical intermediate in the tricarboxylic acid cycle, Over the past few years, the amount of research being done on AKG has significantly increased. Several studies have shown positive effects on the intestinal function....
and AKG promotes stem cell health, stimulates stem cell proliferation, regulates bone and intestinal metabolism, promotes muscle growth and health, and prevents muscle loss due to aging. In addition, AKG is involved in the binding of nitrogen in cells, which can also prevent excessive accumulation...
1 in the intestinal mucosa, and selected hormones, were evaluated. Proliferation, mucosal and submucosal thickness, number of intestinal villi and Paneth cells, and depth of crypts were increased; however, crypt activity, the absorption surface, the expression of claudin 3, MarvelD3, occludin and...
Consistently, aKG supplementation enhanced M1 to M2 macrophage polarization and strengthened intestinal barrier function. Additionally, aKG supplementation elevated colonic aKG levels while decreasing 2﹉ydroxyglutarate levels, which increased oxidative instead of glycolytic metabolism. Conclusion aKG ...