Both enzymes use dioxygen-derived ferryl intermediates in catalysis but, in contrast to IPNS, the ferryl form of DAOCS is produced by the oxidative splitting of a co-substrate, 2-oxoglutarate (alpha-ketoglutarate). This route of controlled ferryl formation and reaction is common to many ...
The quaternary structure of the alpha-ketoglutarate dehydrogenase complex (KGDC) from Escherichia coli has been investigated by electron microscopy. KGDC consists of an octahedral cube-shaped structural core, lipoyl transsuccinylase (E2), to which 12 polypeptide chains each of alpha-ketoglutarate dehydr...
We examined the aforementioned NicX–DHP–NFM complex structure and found that only four subunits (C, D, E, and F) of the six constituent molecules in this structure bind with substrate DHP; the other subunits (A and B) contain the product NFM. This phenomenon of heterogeneous monomer bindi...
. This group is formed from vitamin B6, which is one reason this vitamin is so important in our bodies. PLP works by moving the amino acid into the active site of the enzyme. It also acts as the intermediate in transferring the nitrogen from the amino acid to the alpha-ketoglutarate....
(α-ketoglutarate and Fe (II)), which are necessary to its catalytic function.54Two zinc fingers combine the DSBH and CRD together to form the compact catalytic core.54Although TET proteins are capable of oxidizing 5mC to 5hmC, 5fC and 5caC, structure analysis revealed that TET2 preferred...
Distribution of ω-Amino Acid : Pyruvate Transaminase and Aminobutyrate : α-Ketoglutarate Transaminase in Microorganisms The distribution of -amino acid transaminases in microorganisms was investigated, -Amino acid: pyruvate transaminase (-APT) was found in bacteria and yeast... K Yonaha,K Suzuki,H...
(LEA) hydroxyproline-rich glycoprotein family/other ortho NHL25, leucine-rich repeat family protein, cytochrome P450, dynamin-2B, OsGrx_S17-glutaredoxin subgroup II, lysine ketoglutarate reductase trans-splicing related 1, hydrolase, alpha/beta fold family domain containing protein, pentatricopeptide ...
Dietary α-ketoglutarate supplementation ameliorates intestinal injury in lipopolysaccharide-challenged piglets. Amino Acids. 2010;39:555–64. Article CAS PubMed Google Scholar Hampson DJ. Alterations in piglet small intestinal structure at weaning. Res Vet Sci. 1986;40:32–40. CAS PubMed Google ...
X-ray Crystal Structure of Escherichia coli Taurine/α-Ketoglutarate Dioxygenase Complexed to Ferrous Iron and Substrates , Taurine/alpha-ketoglutarate dioxygenase (TauD), a non-heme Fe(II) oxygenase, catalyses the conversion of taurine (2-aminoethanesulfonate) to sulfite and am... JM Elkins,MJ ...
(α-ketoglutarate and Fe (II)), which are necessary to its catalytic function.54Two zinc fingers combine the DSBH and CRD together to form the compact catalytic core.54Although TET proteins are capable of oxidizing 5mC to 5hmC, 5fC and 5caC, structure analysis revealed that TET2 preferred...