Glutamate and alpha-ketoglutarate: key players in glioma metab- olism. Amino Acids 2017;49(1):21-32.Maus A, Peters GJ. Glutamate and α-ketoglutarate: key players in glioma metabolism. Amino Acids. 2017;49(1):21-32. https://doi.org/10.1007/s00726- 016-2342-9....
(TCA) cycle, which generates α-ketoglutarate and is later transaminated to receive an amino group from abranched chain amino aciddonor,e.g.leucine,isoleucineandvaline, and various amino group donors,e.g.aspartate, γ-aminobutyric acid (GABA) andalanine(Pellerin and Magistretti, 2004). It is...
GPT2 produces glutamate with alanine and alpha-ketoglutarate as precursors, and through electrophysiology, we find that glutamatergic transmission in mouse brain slices is impaired. Also, using biochemical techniques, we observed reduced glutamate levels released from Gpt2-null synaptosomes. In addition, ...
l-Glutamate nutrition and metabolism in swine 2018, Amino Acids The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications 2016, Amino Acids View all citing articles on Scopus Peer review under responsibility of Chinese Association of Animal Science and Veterinary Medicine. ...
Dietary supplementation with glutamate precursor a-ketoglutarate attenuates lipopolysaccharide-induced liver injury in young pigs. Amino Acids 2015;47:1309-18.Dietary supplementation with glutamate precursor alpha-ketoglutarate attenuates lipopolysaccharide-induced liver injury in young pigs. Wang L,Hou Y,Yi ...
Glutamine oxoglutarate aminotransferase (GOGAT) is an enzyme involved in synthesis of glutamate from glutamine and alpha-ketoglutarate. GOGAT has two forms in plants: ferredoxin-dependent GOGAT (Fd-GOGAT) and NADH-dependent GOGAT (NADH-GOGAT). 95% of GOGAT found in plants is the Fd-GOGAT type....
Tet3 is the main α-ketoglutarate (αKG)-dependent dioxygenase in neurons that converts 5-methyl-dC into 5-hydroxymethyl-dC and further on to 5-formyl- and 5-carboxy-dC. Neurons possess high levels of 5-hydroxymethyl-dC that further increase during neura
Glucose is the major substrate for Glu synthesis in astrocytes and neurons[6], and the influx of Na+ (together with Glu through EAATs) stimulates glucose uptake in astrocytes and neurons[7]. Glucose enters the tricarboxylic acids cycle (TCA cycle) and provides α-ketoglutarate (α-KG) as a...
Neither trans-ACPD (an agonist to the metabotropic glutamate receptor) nor the Krebs cycle intermediate alpha-ketoglutarate had any effect on the respiratory rate. An uncontrolled influx of Na+, caused by gramicidin, could mimic the glutamate effect on respiratory activity. In addition, the ...
The reaction (Figure 23.3) occurred in two steps: the first step involves a Schiff base intermediate being formed between ammonia and α-ketoglutarate. This Schiff base intermediate is crucial because it establishes the alpha carbon atom in glutamate’s stereochemistry. The second step involves the ...