The NHS costs of A1AT serum assay, phenotyping and genotyping are 2.45, 35.50 and 87.50. Using the 2010–2012 data, our mean annualised spend on A1AT serum, phenotyping and genotyping was 3,642 3,170 and 376 respectively. The cost per ZZ/SZ case diagnosed was 1198. The highest A1AT ...
AATD = Alpha-1 antitrypsin deficiency; PLC = Primary liver cancer; HCC = Hepatocellular carcinoma; CCA = Cholangiocarcinoma; HCC-CCA = Combined hepatocellular-cholangiocarcinoma; BTC = Biliary tract cancer; ESLD = End stage liver disease. Recently, further insights int...
Since α1AT is commercially available as a drug for treatment of the α1AT deficiency, it could be repurposed for treatment of toxin-mediated diseases. Keywords α1-Antitrypsin, Toxin inhibitor, Clostridium botulinum C2 toxin, Diphtheria toxin, Anthrax toxin, Drug repurposing Clostridium botulinum...
TMPRSS2 (Creative BioMart) was immobilized on a 11-mercaptoundecanoic acid (MUA) functionalized gold sensor chip through covalent coupling of amine groups. The surface was activated using 0.4 M N-hydroxysuccinimide (NHS) and 0.1