Alpha-1-antitrypsin deficiency (AATD) is a rare genetic disorder associated with the development of liver and lung disease. AAT is a 52-kD glycoprotein, produced mainly by hepatocytes and secreted into the blood
AATD, alpha-1 antitrypsin deficiency; ALD, alcohol-related liver disease; HR, hazard ratio; NAFLD, non-alcoholic fatty liver disease; OR, odds ratio; Pi∗MZ, AAT genotype with heterozygosity for the Pi∗Z variant. +/-, conflicting data; +, weak positive evidence; ++, robust positive ev...
Alpha-1抗胰蛋白酶缺乏症的英文名字是Alpha-1 antitrypsin deficiency。基因解码表明:Alpha-1抗胰蛋白酶缺乏症是一种遗传性疾病,与基因突变密切相关。 Alpha-1抗胰蛋白酶是一种由SERPINA1基因编码的蛋白质,它在肝脏中合成并通过血液循环分布到全身。该蛋白质的主要功能是抑制胰蛋白酶的活性,以保护肺部组织免受胰蛋白...
Alpha-1 antitrypsin deficiency associated liver disease (AATD-LD) is a leading genetic cause of liver disease, yet it remains largely underdiagnosed and poorly understood. This encore webinar from a live symposium will feature a multispecialty panel of experts who will...
ARALAST® NP [Alpha1-Proteinase Inhibitor (Human)] is a medication for severe Alpha 1-antitrypsin deficiency with emphysema. See Important Safety Information.
Garcia-Fuentes M, Madrigal V, Alonso J, Lozano MJ, Alvarez- Granda JL. Screning for alpha-1-antitrypsin deficiency in newborn infants in Spain. Pediatric Research 1990; 28: 300 (abstract).GARCIA FUENTES M., MADRIGAL V., ALONSO ]., LOZANO M.]., ALvAREZ GRANDA]. L.: Screening for ...
About Alpha-1 Antitrypsin Deficiency (AATD) and KRRO-110 AATD is a genetic disorder most commonly caused by a single missense mutation (G-to-A) in the SERPINA1 gene. Affected adults experience pulmonary emphysema and/or hepatic cirrhosis, as well as end organ manifestations. KR...
Get information about alpha1-antitrypsin deficiency: disease overview, symptoms, treatment options, PROLASTIN-C Liquid therapy, support program, and more.
--Beam Therapeutics Inc., a biotechnology company developing precision genetic medicines through base editing, today presented additional data from the Phase 1/ 2 clinical trial of BEAM-302 in patients with alpha-1 antitrypsin deficiency at the 2025 Alph
See the effects of alpha1-antitrypsin deficiency.IMPORTANT SAFETY INFORMATION PROLASTIN®-C LIQUID is an alpha1-proteinase inhibitor (human) (alpha1-PI) indicated for chronic augmentation and maintenance therapy in adults with clinical evidence of emphysema due to severe hereditary deficiency of alpha...