Influence of (alpha)-thalassemia on the hematologic changes of homozygous sickle cell diseaseDe Montalembert, MDode, CMaierRedelsperger, MLabie, DGirot, R
Related to Alpha-thalassemia:Beta-thalassemia,hemoglobin H disease thal·as·se·mi·a (thăl′ə-sē′mē-ə) n. An inherited form of anemia occurring chiefly among people of Mediterranean descent, caused by faulty synthesis of part of the hemoglobin molecule. Also calledMediterranean anemia...
Moreover, thalassemia intermedia in mice are exacerbated by the concomitant loss of AHSP (protein or gene; Kong et al 2003). Our results support the idea that a pro-oxidant state occurs in pregnancies complicated by HELLP syndrome (Chen et al 1994; Wisdom et al 1991). There is evidence ...
The role of membrane skeletal-associated alpha-globin in the pathophysiology of beta-thalassemia. Blood 75, 1333–1336 (1990). Article CAS PubMed Google Scholar DeLalio, L. J. et al. Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane. J. ...
Can arise as a result of liver disease, iron deficiency or thalassemia. targeting signal Peptide sequence within a protein that determines where in the cell the protein will be located. Thus there are targeting signals for proteins that accumulate in the nucleus, others for ER, lysosomes and so...
BACKGROUND: Multiplex ligation-dependent probe amplification (MLPA) has been used to detect deletions and mutations of the alpha-globin gene for diagnosis of alpha-thalassemia. MLPA reaction products are usually separated and analyzed by high-voltage capillary gel electrophoresis (CG...
We evaluated 61 patients with two screening tests for alpha-thalassemia traits on the basis of endonuclease gene mapping. Comparing these two methods—the osmotic fragility test of the red cell and modified hemoglobin H inclusion staining for the sensitivity—we found that the latter was much ...
thalassemiairon deficiencyQuantitation of hemoglobin 22 (HbA2) is a basic and confirmatory test in diagnosing the carrier state of -thalassemia. The present study was designed to investigate the effect of cigarette smoking on the diagnostic reliability of HbA2. A total of 2,867 (654 smokers and...
Alpha-thalassemia is related to prolonged survival in sickle cell anemia. Blood. 1983;62(2):286-290.Mears JG, Lachman HM, Labie D, Nagel RL. Alpha- thalassemia is related to prolonged survival in sickle cell anemia. Blood. 62:286-290, 1983....
1993. Unstable alpha-chain hemoglobin variants with factitious beta-thalassemia biosynthetic ratio; Hb Questembert (alpha 131[H14]Ser Pro) and Hb Caen (alpha 132[H15]Val Gly). Am. J. Hematol. 42: 367-374. Wu, G. 1999. The first and second order Markov chain analysis on amino acids ...