Peroxisome proliferator-activated receptors (PPARs, including alpha, beta and gamma subtypes) and their agonists have a protective role in treatment of central nervous system (CNS) diseases. The present study was designed to investigate the expression changes of PPAR-alpha, -beta, -gamma and NF-...
Oral infection with cysts is the main transmission route of Toxoplasma gondii (T. gondii), which leads to lethal intestinal inflammation. It has been widely recognized that T. gondii infection alters the composition and metabolism of the gut microbiota,
The inhibitory effect of norepinephrine on hippocampal type 2 theta activity was found to be mediated by alpha 2-adrenergic receptors. Microinfusions of an alpha 2 agonist (detomidine) mimicked the effects produced by norepinephrine, whereas alpha 1 and beta agonists were ineffective. The ...
This result agrees with Greenspan [20] and Sandvei [41] who demonstrated the presence of EBV receptors in the prickle layer of normal oral epithelium and oral hairy leukoplakia. In the current study, 18 out of the 22 (81.8%) examined squamous cell carcinomas were positive for anti-EBV ...
Steroid receptors are key transducers of hormone signalling and control a wide spectrum of tissue-specific functions that are critical for the physiological homeostasis of reproductive organs. Aberrant or deregulated expressions of steroid nuclear receptors are often associated with cancer progression and hav...
The inhibitory effect of norepinephrine on hippocampal type 2 theta activity was found to be mediated by alpha 2-adrenergic receptors. Microinfusions of an alpha 2 agonist (detomidine) mimicked the effects produced by norepinephrine, whereas alpha 1 and beta agonists were ineffective. The ...
Both receptors are also proteolytically released as soluble molecules capable of binding TNF-α. Inhibition of TNF-α activity as a method of treating disease, in particular, rheumatoid arthritis, has been achieved by a number of different means using inhibitors such as antibodies and soluble ...
P. Hieble, "Pharmacologic and Therapeutic Applications of Alpha-2 Adrenoceptor Subtypes", Annual Review of Pharmacology & Toxicology, Vol. 32 (1993) pp. 243-279. Information regarding alpha adrenergic receptors, agonists and antagonists, in general, and regarding compounds related in structure to ...
Human adrenergic receptors are integral membrane proteins which have been classified into two broad classes, the alpha and the beta adrenergic receptors. Both types mediate the action of the peripheral sympathetic nervous system upon binding of catecholamines, norepinephrine and epinephrine. ...
The present disclosure is directed to antibodies binding to and neutralizing alphavirus, such as EEEV, WEEV or VEEV, and methods for use thereof. Thus, in accordance with the presen