Alpha-1 Antitrypsin (AAT) is a 52 kDa glycoprotein that is principally synthesized by the liver. It is the archetype of the ser-ine protease inhibitor (Serpin) superfamily of proteins, which has a major role in inactivating neutrophil elastase and other proteases to retain protease-antiprotease ...
Alpha1-antitrypsin protects lung cancer cells from staurosporine-induced apoptosis: the role of bacterial lipopolysaccharideElevated levels of plasma alpha1-antitrypsin (AAT) correlate with a poor prognosis of various cancers. Herein, we investigated effects of exogenous AAT on non-small lung cancer ...
Abbreviations AAT: Alpha-1 antitrypsin TNF-α: Tumor necrosis factor-alpha IVD: Intervertebral disc ECM: Extracellular matrix N.P.: Nucleus pulposus NE: Neutrophil elastase RT-qPCR: Real-time polymerase chain reaction References Li D, Zhu B, Ding L, Lu W, Xu G, Wu J. Role of...
Alpha-1 antitrypsin(抗胰蛋白酶) deficiency is a genetic disorder(遗传病) in which a protein called alpha-1 antitrypsin is defective or absent, and it causes lung and liver disease. α抗胰蛋白酶缺乏症是一种遗传性疾病,患者体内的一种叫做α抗胰蛋白酶的蛋白质出现了问题或者含量减少了,最终导致肺...
A1At | alpha-1-antitrypsin 英文名称: A1At | alpha-1-antitrypsin 总访问: 260 国产/进口: 进口 半年访问: 31 产地/品牌: agrisera 产品类别: 抗体 规格: AS101357 最后更新: 2024-12-5 货号: CAS 号: 参考报价: 询价 立即询价 电话咨询 ...
Alpha-1 antitrypsin (A1AT) is an acute-phase protein, and is best known as an inhibitor of the serine proteases, specifically, neutrophil elastase, proteinase 3, and cathepsin G. The discovery of the connection between inherited A1AT deficiency and emphysema resulted in the concept of a protein...
Role of urinary alpha1-antitrypsin in padutin?(kallikrein) inactivation WH H?Rl,RM Sch?Fer,A Heidland 被引量: 0发表: 1982年 Inactivation of urinary kallikrein by alpha 1-antitrypsin. Proteolytic activity, with azocasein as substrate in the presence and absence of 0.4 IU kallikrein (Padutin)...
α1-Antitrypsin plays an important role in neutralizing neutrophil elastase in the lungs. Deficiency of α1-antitrypsin allows neutrophil elastase to destroy the alveolar wall's connective tissue, resulting in emphysema.75 The phenotype for the α1-antitrypsin gene can be assessed.76 Heterozygous ...
Alpha-1 antitrypsin(抗胰蛋白酶)deficiency is a genetic disorder(遗传病)in which a protein called alpha-1antitrypsin is defective or absent, and it causes lung and liver disease. α抗胰蛋白酶缺乏症是一种遗传性疾病,患者体内的一种叫做α抗胰蛋白酶的蛋白质出现了问题或者含量减少了,最终导致肺和肝脏...
An Antiapoptotic Role for {alpha} 1-Antitrypsin in the Prevention of Emphysemaendothelial cells, are exposed to varying amounts of nitric oxide (NO) that is endogenous (i.e., constitutive eNOS or secondary to induction of iNOS in ... Petrache,I. - 《Proceedings of the American Thoracic Soci...