Alpha1-antitrypsin (AAT) deficiency is one of the commonest inherited disorders in white Caucasians. This association has provided major insights into the pathogenesis of chronic lung disease. The three dimensional structure of the protein and the structure of the gene have been determined. Some of...
Alpha 1 antitrypsin (AAT) is a serine proteinase inhibitor (serpin). One well-known function of this protein is to inactivate neutrophil elastase and other neutrophil-derived proteinases, and prevent the destruction of pulmonary extracellular matrix. Deficiency of AAT can cause emphysema due to ...
炎症标志物—α1-抗胰蛋白酶 AAT α1-抗胰蛋白酶是一种糖蛋白,是一种急性时相反应蛋白。 指标升高:主要见于组织损伤,感染性疾病(细菌性、病毒性)、恶性肿瘤、病毒性肝炎、胶原病、妊娠、外科手术、药物(雌激素、口服避孕药、肾上腺类固醇、前列腺素等),斑疹伤寒等。 指标降低:主要见于遗传性α1-AT缺乏症,由...
Alpha 1 Antitrypsin Treatment during Human Ex Vivo Lung Perfusion Improves Lung Function by Protecting Lung EndotheliumPurpose The majority of potential donor lungs are not being used. The primary reason for underutilization is the concern for primary graft dysfunction (PGD). There is currently no ...
Diagnosis of alpha-1 antitrypsin deficiency often begins with a chest X-ray or Chest CT to look for hyperinflated(过度膨胀) lungs or evidence of damaged lung tissue. 一般诊断的话肺就看胸片或者CT,或者找到一些肺损伤的证据 In addition, pulmonary function testing can be used to measure how quickl...
Alpha-1 antitrypsin deficiency (AATD) is a significantly under-diagnosed genetic condition caused by reduced levels and/or functionality of alpha-1 antitrypsin (AAT), predisposing individuals to lung, liver or other systemic diseases. The management of individuals with the PI*MZ genotype, characterized...
A decreased concentration of alpha 1-antitrypsin is associated with a high risk for obstructive lung disease. We measured the elastase inhibitory capacity, the most important biologic measure of alpha 1-AT function, using a natural substrate. The gel plate assay that we developed uses a commercial...
Smoking and intermediate alpha1-antitrypsin deficiency and lung function in middle-aged men. Smoking and intermediate alpha1- antitrypsin deficiency and lung function in middle-aged men. BMJ 1977;2:922-5.Larsson, C., Eriksson, S., and Dirksen, H., 1977, Smoking and intermediate alpha 1 -...
Protein Function:: SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antitrypsin is mainly produced in the liver and acts as an ant...
Diagnosis of alpha-1 antitrypsin deficiency often begins with a chest X-ray or Chest CTto look for hyperinflated(过度膨胀)lungs or evidence of damaged lung tissue. 一般诊断的话肺就看胸片或者CT,或者找到一些肺损伤的证据 In addition, pulmonary function testing can be used to measure how quickly ...