Alpha-1抗胰蛋白酶(Alpha-1 Antitrypsin,简称AAT)是由SERPINA1基因编码的一种血清蛋白,主要在肝脏中合成。AAT属于丝氨酸蛋白酶抑制因子家族,其主要功能是通过抑制中性粒细胞弹性蛋白酶(NE)来保护肺泡组织免受酶解性损伤。因此,AAT的缺乏或功能异常会导致多种疾病,尤其是肺部和肝脏相关病症。 【佳学基因检测】Alpha-1...
The abundant serum protein alpha-1 antitrypsin (AAT) is the prototype chronic obstructive pulmonary disease (COPD) biomarker. AAT is an antiprotease which inhibits neutrophilderived proteases and protects the fragile tissues of the lung. Absence of this key antiprotease renders t...
Alpha-1抗胰蛋白酶缺乏症的英文名字是Alpha-1 antitrypsin deficiency。基因解码表明:Alpha-1抗胰蛋白酶缺乏症是一种遗传性疾病,与基因突变密切相关。Alpha-1抗胰蛋白酶是一种由SERPINA1基因编码的蛋白质,它在肝脏中合成并通过血液循环分布到全身。该蛋白质的主要功能是
Alpha 1 is the common name for a genetic condition called Alpha 1 Antitrypsin Deficiency. If a person has Alpha 1, the body is unable to produce a protein known as Alpha 1 Antitrypsin, or AAT for short. This protein plays an important role in protecting the lungs from damage due to exce...
antitrypsin (alpha1-AT) replacement therapy for those with emphysema resulting from alpha1-ATD. In addition, poorly controlled asthma may accelerate the deterioration of lung function in patients with alpha1-ATD (and perhaps also in those with non-alpha1chronic obstructive pulmonary disease [COPD])...
Alpha1-antitrypsin deficiency (alpha-1) is a rarely diagnosed genetic disease often called "genetic COPD" because it can be passed down through families. If you havealpha-1, your body does not make enough alpha1antitrypsin, a protein that protects your lungs.2 ...
Alpha-1 antitrypsin (AAT) deficiency is the #1 genetic risk factor for COPD. Screen all COPD patients with AlphaID™; a comprehensive genetic screening test for AAT deficiency.
吸烟可能会导致COPD的发生这大家知道的,如果吸烟加抗胰蛋白酶缺乏?←_← The gene that encodes alpha-1 antitrypsin protein is called SERPINA1, which stands forserpin peptidase inhibitor(丝氨酸蛋白酶抑制剂), clade A, member 1.While some mutations in SERPINA1 completely abolish the genemessage meaning no...
INTRODUCTION: Alpha-1-antitrypsin deficiency (AATD) is an orphan disease that predisposes individuals to COPD and liver disease. The following is a comprehensive review of AATD from epidemiology to treatment for physicians who treat COPD or asthma. Areas covered: In this comprehensive revi...
【佳学基因检测】Alpha 1 抗胰蛋白酶突变基因检测Alpha 1 Antitrypsin MutationAlpha 1 抗胰蛋白酶基因突变基因检测Alpha-1 抗胰蛋白酶是一种主要在肝脏中产生的蛋白酶抑制剂。它抑制肺中的中性粒细胞弹性蛋白酶活性,因此可以保护它免受蛋白水解损伤。它负责大约 90% 的保护,以防止由嗜中性粒细胞释放的弹性蛋白酶...