Alpha-1 antitrypsin deficiency alleles and severe cystic fibrosis lung disease . Thorax 53 , 1022–102410.1136/thx.53.6.501 [ PMC free article ] [ PubMed ] [ Cross Ref ]Mahadeva R, Stewart S, Bilton D, Lomas DA. Alpha-1 antitrypsin deficiency alleles and severe cystic fibrosis lung ...
Glasgow JFT, Hercz A, Levison H, Lynch MJ, Sass-Kortsak A (1971) Alpha-1-antitrypsin (AT) deficiency with both cirrhosis and chronic obstructive lung disease in two sibs. Pediatr Res 5: 427GLASGOW, J.F.T., HERCZ, A., LEVISON, H., LYNCH, M.J. & SASS KORTSAK, A. (1971) ...
alpha1‐antitrypsin deficiencyaugmentation therapychronic obstructive pulmonary diseaseemphysemaAATD is a common inherited disorder associated with an increased risk of developing pulmonary emphysema and liver disease. Many people with AATD゛ssociated pulmonary emphysema remain undiagnosed and therefore without ...
objective: to determine the levels of alpha-1 antitrypsin (aat) and the presence of s and z alleles in patients with chronic respiratory symptoms. methods: patients with chronic cough and dyspnea were submitted to clinical evaluation, pulmonary function tests, high-resolution computed tomography, nep...
Alpha-1 antitrypsin(抗胰蛋白酶)deficiency is a genetic disorder(遗传病)in which a protein called alpha-1antitrypsin is defective or absent, and it causes lung and liver disease. α抗胰蛋白酶缺乏症是一种遗传性疾病,患者体内的一种叫做α抗胰蛋白酶的蛋白质出现了问题或者含量减少了,最终导致肺和肝脏...
Correlation of Alpha-1 Antitrypsin and Smoking in Chronic Obstructive Lung Disease: An Observational StudySetting- The present study was carried out in the Department of Physiology, Biochemistry & Medicine Govt. Medical College, Aurangabad, Maharashtra, India. Objective- To correlate serum AAT levels ...
Alpha1-antitrypsin deficiency (AATD) was first described by Laurell and Eriksson in 1963. Laurell noted the absence of the band of alpha1- protein in 5 of 1500 serum protein electrophoreses (SPEP) submitted to his laboratory in Sweden.
Alpha-1-antitrypsin deficiency (AATD) is a rare genetic disorder associated with the development of liver and lung disease. AAT is a 52-kD glycoprotein, produced mainly by hepatocytes and secreted into the blood. Agglomeration of the AAT-protein in hepatocytes can result in liver disease. Exposur...
Alpha-1 Antitrypsin Deficiency (A1AD) is a hereditary condition characterized by low levels of circulating alpha-antitrypsin (AAT) in plasma. It is the best understood genetic risk factor for the development of chronic obstructive pulmonary disease (COPD). The diagnosis of A1AD is under-recognized...
Alpha-1-Antitrypsin Deficiency – Molecular Basis, Clinical Presentation, Therapeutic Options and an Integrative Approach in Diagnostics / DEFICIJENCIJA AL... The primary role of alpha-1-antitrypsin (AAT), encoded by the highly polymorphic SERPINA1 gene, is to protect the lung parenchyma from proteo...