market. They are imipenem/cilistatin, meropenem, ertapenem and doripenem, which are four beta lactam antibiotics of the carbapenem class. Carbopenems are used to treat infections and in clinical practice, these are the go-to ...
Clavulanic acid is a potent inhibitor of beta-lactamase enzymes and is of demonstrated value in the treatment of infections by beta-lactam-resistant bacter... R Li,N Khaleeli,CA Townsend - 《Journal of Bacteriology》 被引量: 108发表: 2000年 The ramC gene is required for morphogenesis in St...
β-Lactams are the most commonly used antibiotics in intensive care units (ICUs). As critically ill patients often experience pharmacokinetic aberrations, and rates of antimicrobial resistance vary between hospital settings, reliance on tertiary sources or package labeling to guide empiric dosing often ...
Can penicillins and other beta-lactam antibiotics be used to treat tuberculosis? An increase in the number of tuberculosis cases caused by multiple-drug-resistant strains of Mycobacterium tuberculosis has stimulated search for new antit... H,F,Chambers,... - 《Antimicrobial Agents & Chemotherapy》...
A survey of the utilization of anti-pseudomonal beta-lactam therapy in cystic fibrosis patients. The purpose of this study was to characterize the utilization of anti-pseudomonal beta-lactam antibiotics in the treatment of acute pulmonary exacerbations... JT Zobell,DC Young,CD Waters,... - 《...
Analysis of a carbapenem-hydrolyzing class A beta-lactamase from Enterobacter cloacae and of its LysR-type regulatory protein Carbapenems such as imipenem are extended-spectrum β-lactam antibiotics, which are not hydrolyzed by the β-lactamases commonly found in Enterobacteriacea... T Naas,P Nordman...
ofa内酰胺allvia1beta 系统标签: pharmacophorelactambeta药效diversificationceh Diversificationofab-lactampharmacophoreviaallylicCeHamination:acceleratingeffectofLewisacidco-catalystXiangbing(Ben)Qia,GrantT.Ricea,ManjinderS.Lallb,MarkS.Plummerb,M.ChristinaWhitea,*aRogerAdamsLaboratory,DepartmentofChemistry,Univers...
The18 interaction of such transporters with β-lactam antibiotics has been studied extensively in19 vitro (10, 23, 25). However, the in vivo role of transporters in drug disposition, in the20 context of other transporters, glomerular filtration, and metabolism, has not been21 established. Thus...
49 Introduction: 50 Ceftolozane-tazobactam (C/T) is a new beta-lactam/beta-lactamase inhibitor combination agent 51 that combines a novel oxyimino-cephalosporin (ceftolozane) with an established beta-lactamase 52 inhibitor (tazobactam). C/T was approved by the U.S. Food and Drug Administration ...
or other drugs. If this product is to be given to penicillin-sensitive patients, caution should be exercised because cross hypersensitivity among beta-lactam antibiotics has been clearly documented and may occur in up to 10% of patients with a history of penicillin allergy. If an allergic reactio...