BETA lactam antibioticsBURN patientsPHARMACOLOGYINJURY complicationsDRUG monitoringBackground: Burn injury causes profound pathophysiological changes in the pharmacokinetic/pharmacodynamic (PK/PD) properties of antibiotics. Infections are among the principal complications after burn injurie...
pneumoniae produces carbapenemase, the most evolved β-lactamase currently in evidence, which can inactivate almost all classes of β-lactam antibiotics7,8. Other antibiotic resistance mechanisms such as the overproduction of class C beta-lactamases, expression of the MDR efflux pump or an ESBL ...
Why are beta-lactam antibiotics generally more effective against gram-positive bacteria than against gram-negative bacteria? What group does the microorganism that causes the disease belongs to? ''Gangrene '' Groups: Gram-Positive Bacteria, Gram-Negative Bacteria, Protozoa, Fungi, Viruses What is a...
As corroborated in the past by the development of beta-lactam antibiotics, an infection can most effectively be treated using compounds whose mode of action either triggers the formation of covalent bonds or avoids that these bonds are broken. Accordingly, several nucleoside analogues and protease ...
What are the long-term effects of the overuse of antibiotics? What mechanisms might arise to allow resistance to the beta-lactam antibiotics? In what way does the use of antibiotics impose selective pressure on bacteria? What is antibiotic resistance? How do bacteria become...
(which confers resistance to beta-lactam antibiotics, of which methicillin, the m in mrsa, was the first). they then subdivided the isolates based on the short string of genetic material in which the mec gene resides, known as scc mec (scc stands for "staphylococcal chromosomal cassette"). ...
β-Lactams are a broad class of antibacterial agents that inhibit penicillin-binding proteins (PBPs) essential for transglycosylation and transpeptidation of peptidoglycan strands during bacterial cell wall biosynthesis (1). Many β-lactam antibiotics have been developed and extensively used in the clin...
Recent findings have suggested that the 1-methyltetrazole-5-thiol (MTT) group contained in several beta-lactam antibiotics may be responsible for the hypop... J J,Lipsky,J C,... - 《Journal of Antimicrobial Chemotherapy》 被引量: 9发表: 1986年 Role of the thioredoxin system and the thiol...
Tumours of the peripheral nervous system appear at irregular intervals in adult individuals; however, barring a few specific types, these growths are generally benign. The most commonplace and consistent growths are nerve sheath tumors. These tumors' close proximity to or even intrusion into peripher...
.beta.-LACTAM ANTIBIOTICS, PROCESSES FOR THEIR PREPARATION AND AGENTS WHICH CONTAIN THESE COMPOUNDS23189-5570DAbstract of the DisclosureThe invention relates to compounds of formula (III)wherein A is lower alkyl or unsubstituted phenyl and n is 1 or 2,\nand protected and reactive derivatives ...