First-generation cephalosporins inhibit bacterial cell wall synthesis and have the same mode of action as other beta-lactam antibiotics (such as penicillins). They disrupt the synthesis of the peptidoglycan layer forming the bacterial cell wall. The peptidoglycan layer is important for cell wall struc...
Penicillinase-resistant penicillins (also referred to as second-generation penicillins) are antibiotics that are resistant to the bacterial enzyme beta-lactamase and are used to treat staphylococcal and streptococcal bacterial infections. Penicillinase-resistant penicillins are semisynthetic modifications of n...