Context: Nucleophilic substitution reactions of aliphatic amines with alkyl halides represent a simple and direct mechanism for obtaining higher-order aliphatic amines. However, it is well known that these reactions suffer from low selectivity due to multiple alkylations, which is att...
C. Fu, Transition-metal- catalyzed alkylations of amines with alkyl halides: Photoinduced, copper-catalyzed couplings of carbazoles. Angew. Chem. Int. Ed. 52, 5129-5133 (2013).A. C. Bissember, R. J. Lundgren, S. E. Creutz, J. C. Peters and G. C. Fu, Transition-Metal-Catalyzed ...
Here we show that the selective N-alkylation of amines with alcohols can be catalysed by defined PNP manganese pincer complexes. A variety of substituted anilines are monoalkylated with different (hetero)aromatic and aliphatic alcohols even in the presence of other sensitive reducible functional ...
Although the N-alkylation of aliphatic amines with alkyl halides has been widely adopted for over 100 years, catalyst poisoning and unfettered reactivity have been preventing the development of a catalyst-controlled enantioselective version3,4,5. Here we report the use of chiral tridentate anionic ...
ChemInform Abstract: N-ALKYLATION OF AMINES AND AMIDES CATALYZED BY AMMONIUM HALIDESalkylation, arylation, dealkylation, dearylation, C‐acylation, olefinationNo abstract is available for this article.doi:10.1002/chin.198031147H.KASHIWAGIS.ENOMOTO
These derivatives are readily obtained byalkylationof 2 - mercaptopyridine and alkyl halides under alkaline conditions. 这些衍生物可以容易地在碱性条件下通过 2- 巯基吡啶和卤代烷的烷基化而得到. 辞典例句 The different contents of variousalkylationproducts were obtained with different catalysts. ...
A greener improvement to direct mono-N-alkylation of aromatic amines by alkyl halides was achieved using microwave irradiation in water without any catalyst. G Marzaro,A Guiotto,A Chilin - 《Cheminform》 被引量: 65发表: 2009年 Catalyst comprising at least one zeolite with structure type NES and...
Nucleophilic difluoromethylation of primary alkyl halides using difluoromethyl phenyl sulfone as a difluoromethyl anion synthon. Org Lett, 2003, 6: 4315–4317 Article Google Scholar Chen QY, Zhu SZ. Perfluoro- and polyfluorosulfonic acids. XIV. Formation of difluorocarbene from difluoromethane...
Electroreductive N-alkylation of amides, carbamates, and N-heterocycles The N-alkylation of amides, lactams, carbamates, and N-heterocycles was easily attained in good yields by the electroreduction of the substrates in the presence of alkyl halides. T Shono,S Kashimura,H Nogusa - 《Chemistry ...
1a. The alkylamino functionality is essential for drug design, as they often improve the oil-water partition coefficient (log P), reduce their toxicity, and increase their bioavailability (prodrugs)3. Figure 1 A mixture of two photocatalysts enables rapid N-alkylation of amines with alcohols ...