The alkylating agents are a diverse group of anticancer drugs that covalently bind an alkyl group or a substituted alkyl group to cellular constituents. Their common property is the capacity to become strong el
Alkylating agents are small molecules that can covalently bind an alkyl group to electron-rich nucleophilic moieties to form adduct and exert cytotoxic effect on cancer cells by binding to DNA molecules. From: How Synthetic Drugs Work, 2023 ...
烷化剂(alkylating agents)是指在体内能形成正碳离子的亲电子基团,以攻击生物大分子的负电子位点的物质。可分为双功能 … www.360doc.com|基于138个网页 2. 烷基化药物 烷基化药物(Alkylating agents)1. 机转 与此 Web 有关的问题请直接送至 [电子邮件 drho123@gmail.com] 。
alkylating agents释义 常用 牛津词典 释义 [医]烷化剂(抗肿瘤药);双语例句 全部 1. The hydrocarbon diperchlorate products have utility as detonatable sensitizers for explosives and alkylating agents. 二过氯酸烃基酯产物可用作起爆药的敏化剂及作为烷化剂. 来自辞典例句拍照翻译 语音翻译 智能背词 下载金山...
必应词典为您提供alkylatingagents的释义,网络释义: 烃基化剂;烷化剂;烷基化药物;
生物烷化剂(bioalkylating agents) 相关知识点: 试题来源: 解析 也称烷化剂,属于细胞毒类药物,在体内能形成缺电子活泼中间体或其他具有活泼的亲电性基团的化合物,进而与生物大分子(如DNA、RNA或某些重要的酶类)中含有丰富电子的基团(如氨基,巯基、羟基、羧基、磷酸基等)进行亲电反应和共价结合,使生物大分子丧失...
Alkylating agents are compounds that work by adding an alkyl group to the guanine base of the DNA molecule, preventing the strands of the double helix from linking as they should. This causes breakage of the DNA strands, affecting the ability of thecancercell to multiply. Eventually, the cance...
也称烷化剂,抗肿瘤药中使用最早的一类。 1、作用机理: 在体内形成缺电子活泼中间体,及其它有活泼亲电基团的化合物,与生物大分子 (DNA,RNA或酶)中含有丰富电子的基团,亲电共价结合,使大分子失活,阻 ...
1、生物烷化剂(bioalkylating agents)(生物烷化剂(生物烷化剂)生物烷化剂(生物烷化剂)也称烷化剂,抗肿瘤药中使用最早的一类。1、作用机理:在体内形成缺电子活泼中间体,及其它有活泼亲电基团的化合物,与生物大分子(DNA,RNA或酶)中含有丰富电子的基团,亲电共价结合,使大分子失活,阻碍其正常生理功能。2、缺点:...
Alkylating agents are a class of anti-cancer chemotherapy drugs that bind to DNA and prevent proper DNA replication [4]. The monofunctional alkylating agents dacarbazine (DTIC) and temozolomide (TMZ) are approved in USA and frequently used for the treatment of melanoma for first-line therapy, but...