Alkylating agents are among the first group of chemicals determined to be useful in cancer chemotherapy . They remain to be the most important components of modern chemotherapeutic protocols (individually or in combination with other drugs) because of their proved and significant clinical anticancer ...
antineoplastic,antineoplastic drug,cancer drug- any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function ...
Alkylating agents (al-ka-LAYT-ing AY-jints) are a family of anticancer drugs that interfere with cell’s DNA and inhibit cancer cell growth. They are so named because of their ability to add alkyl groups to negatively charged groups on biological molecules such as DNA and proteins. Alkylati...
Alkylating agents play a significant role in the treatment of lymphoma, Hodgkin's disease, breast cancer, multiple myeloma, and other malignancies. In addition to conventional chemotherapy, the linear dose–response curve of alkylating agents expands their role for incorporation into transplant regimens....
3. Most alkylating agents were discovered based on their efficacy against cancer cells, so off-target effects on normal tissues are inevitable. Therefore, DNA damage from alkylating chemotherapy increases the risk of genetic mutations in normal tissues that can induce de novo cancer without a proper...
The number of alkylating agents used in chemotherapy is too long to cite in this brief review. To provide some examples, there are monofunctional methylating agents (temozolomide or TMZ), larger monofunctional alkylating agents (cyclohexyl chloroethyl nitrosourea, CCNU, or lomustine)[Figure 1]. The...
Balancing repair and tolerance of DNA damage caused by alkylating agents. Nat Rev Cancer 12, 104–120 (2012). https://doi.org/10.1038/nrc3185 Download citation Published12 January 2012 Issue DateFebruary 2012 DOIhttps://doi.org/10.1038/nrc3185 Subjects Chemotherapy DNA damage and repair Genomic...
Due to the aggressiveness, melanoma is often diagnoses at the advanced stages and the general treatments, surgery and radio/chemotherapy, are not respond. Show abstract A TCM formula comprising Sophorae Flos and Lonicerae Japonicae Flos alters compositions of immune cells and molecules of the STAT3 ...
If there were a stigma scale for chemotherapy, alkylating agents would be ranked at the top of the list. The chemical term alkylation is associated with nonselective toxicity, an association that dates back to the use of nitrogen mustards during World War I as chemical warfare agents. That th...
Alkylation agents are a large group of drugs (altretamine, busulfan, carmusine, chlorambucil, cytoxan, dacarbazine, ifosfamide, lomustine, merchlorethamine, melphalan, procarbazine, temozolamide, thiotepa, streptozocin) which are used in various carcinomas. This group of chemotherapy causes cell dam...