The use of alkylating agents as chemotherapy dates from 1946, the year that nitrogen mustard was introduced. Sulfur mustard was used as a warfare agent because of its vesicant effect on the skin and mucous membranes. The observation of its additional effect of hematopoietic and lymphoid system ...
Alkylating agents (al-ka-LAYT-ing AY-jints) are a family of anticancer drugs that interfere with cell’s DNA and inhibit cancer cell growth. They are so named because of their ability to add alkyl groups to negatively charged groups on biological molecules such as DNA and proteins. Alkylati...
Alkylation agents are a large group of drugs (altretamine, busulfan, carmusine, chlorambucil, cytoxan, dacarbazine, ifosfamide, lomustine, merchlorethamine, melphalan, procarbazine, temozolamide, thiotepa, streptozocin) which are used in various carcinomas. This group of chemotherapy causes cell dam...
antineoplastic,antineoplastic drug,cancer drug- any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function ...
Alkylating agentsare most widely used anticancer drugs and are major components of combination chemotherapy[14]. These are small molecules that can covalently bind an alkyl group to electron-rich nucleophilic moieties to form adducts and, hence, have acytotoxic effect on cells by binding to DNA mol...
"I was surprised at the substantial overlap of cumulative doses among the normospermic, oligospermic, and azoospermic participants. This suggests that factors other than cumulative drug dose are important in determining chemotherapy toxicity to spermatogenesis," Dr. Green said. ...
Twitter Google Share on Facebook alkylation (redirected fromAlkylating agents) Medical Encyclopedia Related to Alkylating agents:Antimetabolites al·kyl·ate (ăl′kə-lāt′) tr.v.al·kyl·at·ed,al·kyl·at·ing,al·kyl·ates To add one or more alkyl groups to (a compound). ...
The alkylating agents cyclophosphamide and chlorambucil have been utilized in medicine for over 50 years. As our knowledge about the pharmacokinetics of these agents has grown, treatment regimens have evolved. While alkylating agents have been shown to be highly effective in the treatment of ocular in...
Chemotherapeutic efficacy, the ability of chemotherapy to eradicate tumor cells without causing lethal host toxicity, depends of drug selectivity. The basis for anticancer drug selectivity is not completely understood. One class of anticancer drugs, alkylating agents, cause cell death by binding to DNA...
The compounds of the present invention can be administered either as single agents or, alternatively, in combination with known anticancer treatments such as radiation therapy or chemotherapy regimen, in combination with cytostatic or cytotoxic agents, antibiotic-type agents, alkylating agents, antimetaboli...