Alkylating agents hold an important place in the array of drugs available for clinical cancer chemotherapy. Chemically alkylating agents are compounds (RX) which react with nucleophilic (electron-donating) centres (Y) to form covalently bound products (RY) containing the alkyl group (R). The ...
Alkylating agents were among the first anticancer drugs to be discovered, after observing their effects during their use as chemical weapons during the First World War. Nowadays they are still the most commonly used pharmacological compounds in chemotherapy. Alkylating agents are electrophiles that react...
antineoplastic,antineoplastic drug,cancer drug- any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function ...
3. Most alkylating agents were discovered based on their efficacy against cancer cells, so off-target effects on normal tissues are inevitable. Therefore, DNA damage from alkylating chemotherapy increases the risk of genetic mutations in normal tissues that can induce de novo cancer without a proper...
Due to the aggressiveness, melanoma is often diagnoses at the advanced stages and the general treatments, surgery and radio/chemotherapy, are not respond. Show abstract A TCM formula comprising Sophorae Flos and Lonicerae Japonicae Flos alters compositions of immune cells and molecules of the STAT3 ...
Treated and untreated Nf1+/− mice were also compared to ascertain the relative contributions of Nf1 genotype and chemotherapy exposure to leukemia susceptibility. This analysis showed that the incidence of disease was significantly higher, and the latency period shorter, in the Nf1+/− mice ...
A. P., Iatsyshyna. (2012) Current approaches to improve the anticancer chemotherapy with alkylating agents: state of the problem in world and Ukraine. Biopolymers and Cell 28 :10.7124/bc.28.2, 83-92 /Iatsyshyna A. Current approaches to improve the anticancer che- motherapy with alkylating...
ChemotherapyAnticancer drugProdrugResistanceGlutathione S-transferaseAlkylating agents were the first anticancer molecules developed and are still used today. The family contains 6 major classes: nitrogen mustards, aziridines, alkyl sulfonates, epoxides, nitrosoureas and triazene compounds. Due to their ...
Mehrling, “The Alkylating-HDAC Inhibition Fusion Principle Taking Chemotherapy to the next Level with the First in class Molecule EDO-S101” Anti-Cancer Agents in Medicinal Chemistry, 2016, (16) pp. 20-28. Miller, et al., “Histone Deacetylase Inhibitors,” J. Med. Chem., 46(24):5097...
LH treatment protects mouse primordial follicles against alkylating agents by preventing the chemotherapy-induced follicular depletion and the impairment of oocyte-GC communication during follicular growth. WHAT IS KNOWN ALREADY. Impaired folliculogenesis is one of the most common deleterious side effects of...