Alkylating agents were among the first anticancer drugs to be discovered, after observing their effects during their use as chemical weapons during the First World War. Nowadays they are still the most commonly
Alkylating agents hold an important place in the array of drugs available for clinical cancer chemotherapy. Chemically alkylating agents are compounds (RX) which react with nucleophilic (electron-donating) centres (Y) to form covalently bound products (RY) containing the alkyl group (R). The ...
antineoplastic,antineoplastic drug,cancer drug- any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function ...
Alkylating agents are a class of anti-cancer chemotherapy drugs that bind to DNA and prevent proper DNA replication [4]. The monofunctional alkylating agents dacarbazine (DTIC) and temozolomide (TMZ) are approved in USA and frequently used for the treatment of melanoma for first-line therapy, but...
We further explored the interaction between MLN4924 and the chemotherapy agents commonly used in treatment of CLL, bendamustine and chlorambucil. Although these alkylating agents induce DNA crosslinking and DNA damage at all phases of the cell cycle, they are most toxic to cells that progress through...
2022, New Strategies Targeting Cancer Metabolism Anticancer Drugs Synthetic Analogues and Antitumor Agents Encapsulated cells expressing a chemotherapeutic activating enzyme allow the targeting of subtoxic chemotherapy and are safe and efficacious: Data from two clinical trials in pancreatic cancer 2014, Pharm...
Chemotherapeutic efficacy, the ability of chemotherapy to eradicate tumor cells without causing lethal host toxicity, depends of drug selectivity. The basis for anticancer drug selectivity is not completely understood. One class of anticancer drugs, alkylating agents, cause cell death by binding to DNA...
Comparison of the Emetogenic Potential Between Cisplatin and Carboplatin in Combination with Alkylating AgentsCISPLATINTISSUE CONCENTRATIONSBRAIN TUMORSRADIATIONPlatinum-based poh chemotherapy is widely used in the treatment of gynecological cancer. Emesis is one of the most disturbing side-effects of platinum...
Current treatment approaches are based on radiation therapy and alkylating agent chemotherapy. O6-guanine alkylating agents, such as 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and temozolomide (TMZ), are among the most widely used chemotherapeutics in treating glioblastomas because they can ...
The compounds of the present invention can be administered either as single agents or, alternatively, in combination with known anticancer treatments such as radiation therapy or chemotherapy regimen, in combination with cytostatic or cytotoxic agents, antibiotic-type agents, alkylating agents, antimetaboli...