Unfortunately the chemical processes are not tumour-selective and the in vivo effects of alkylating agents are seen in all dividing cells to which these drugs have access. Frequently the side effects that occur with alkylating agent treatment limit the dose of the compound that can be used for ...
Noun1.alkylating agent- an antineoplastic drug used to treat some forms of cancer antineoplastic,antineoplastic drug,cancer drug- any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiti...
This group of chemotherapy causes cell damage by alkylating the guanine base of the DNA double helix. Therefore, the affected cells are growth inhibited, and apoptosis (spontaneous cell death) will be stimulated. Altretamine is an oral agent which is used for ovarian carcinoma. Busulfan is used...
In humans, only HCQ and CQ inhibitors have been tested in combination with conventional chemotherapy. Several studies now in preclinical phase are being conducted combining these inhibitors with chemotherapeutic drugs [30]. However, temozolomide is the only alkylating agent so far tested. Currently, ...
et al. The translesion polymerase Rev3L in the tolerance of alkylating anticancer drugs. Mol. Pharmacol. 76, 927–934 (2009). This paper and references 10, 22 and 23 show that TLS polymerases have a crucial role in determining alkylating agent sensitivity through the bypass of replication-...
MGMT and MMR, it is possible that mispairing occurs that leads to cell death[Figure 2], but that is not reported. Moreover, understanding the links between the MGMT and ALKBH pathways is important to the understanding of how tumor cells protect themselves against alkylating agent chemotherapy. ...
- 《Cancer Chemotherapy & Pharmacology》 被引量: 21发表: 1994年 Pharmacokinetics of anticancer agents in humans / Cyclophosphamide, cisplatin, and carmustine (CPA/cDDP/BCNU) constitute a combination alkylating-agent regimen commonly used with autologous marrow support... M Matthew - Elsevier ; 被引...
Experiments were carried out to determine whether the enhancement of alkylating-agent cytotoxicity seen after large single doses of misonidazole (MISO) in ... J M,Brown,D G,... - 《British Journal of Cancer》 被引量: 43发表: 1982年 The effect of alkylating agents on adenosine 3',5'-...
Multiple agent chemotherapy (POACH) in previously treated and untreated patients with chronic lymphocytic leukemia Leukemia 1988 2: 157–164 CAS PubMed Google Scholar O'Brien S, Kantarjian H, Beran M, Smith T, Koller C, Estey E, Robertson LE, Lerner S, Keating M . Results of fludarabine ...
alkylating agent with two active bischloroethyl groups that can react with separate bases in DNA to form interstrand crosslinks in addition to monoadducts or intrastrand crosslinks. Bu is a unique SN2-type alkylating agent with alkyl sulfonate groups that can induce monoadducts or intrastrand ...