PROBLEM TO BE SOLVED: To provide a rodent that can be used as an animal model reflecting BMP signaling through ALK2 in a primate such as human.;SOLUTION: A rodent has a rodent-mutant ALK2 gene having a mutation at a position encoding a 330-th amino acid of an ALK2 protein. In the...
Mutations in this gene are associated with fibrodysplasia ossificans progressive. 关键字: Activin RIA;Activin RIA蛋白;ALK2蛋白;ACRO;百普赛斯; 公司简介 百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业...
PROBLEM TO BE SOLVED: To provide a rodent that can be used as an animal model reflecting BMP signaling through ALK2 in a primate such as human.;SOLUTION: A rodent has a rodent-mutant ALK2 gene having a mutation at a position encoding a 330-th amino acid of an ALK2 protein. In the...
ACVR1 激活素是属于结构相关信号蛋白转化生长因子β(TGFβ)超家族的二聚生长和分化因子。激活素通过受体丝氨酸激酶的异聚体复合物传递信号,该复合物包括至少两个I型(I和IB)和两个II型(II和IIB)受体。这些受体都是跨膜蛋白,由一个与富含半胱氨酸区域结合的配体胞外结构域、一个跨膜结构域和一个具有预测丝氨酸/...
13., 14. Somatic missense mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1 gene encoding activin receptor-like kinase-2 (ALK2), one of the seven (ALK1–7) type I receptors in the transforming growth factor β (TGFβ)/BMP signaling pathway, have been reported in ...
promotestheEndMT.Inaddition,mutationinthe206aminoacidofthegenesequencewhichencodes ALK2,formsR206HALK2,causingactiveALK2intheend.Thiswaycanpromotethetransitionofen— dothelialcellsintomesenchymalceilsaswel1. [Keywords] ALK2; Endothelialcells; Stem—likecells; ...
The ZytoDot ® 2C SPEC ALK Break Apart Probe is designed to detect rearrangements involving the chromosomal region 2p23.2 harboring the ALK (anaplastic lymphoma receptor tyrosine kinase, a.k.a. CD246) gene by Chromogenic in situ Hybridization (CISH). A
ALK2抗体及其使用方法.pdf,本发明的特征在于ALK2抗体及其抗原结合片段(例如,ALK2结合片段)。本发明的特征还在于使用ALK2抗体或其抗原结合片段来治疗骨疾病或损伤、低红血细胞水平(例如,贫血或失血)、异位骨化(例如,由进展性骨化性纤维发育不良导致的异位骨化)、干燥综合
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receptor. ACVR1 has been demonstrated to form complex with either the BMP-2/7-bound BMPR-II or ACVR2A/ACVR2B and transduce signals to downstream components R-SMADs. Recombinant soluble ALK2 does not bind activin. Mutations in this gene are associated with fibrodysplasia ossificans progressive....