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TP53突变在预后中的作用值得进一步研究。 This study illustrated the patterns of EML4-ALK fusion variants and gene profiles in patients with resected NSCLC. Advanced T stage and EML4-ALK variant 3 were associated with worse p...
6、Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007;448(7153):561-566. 7、黄浩祺,刘志华,陈洁,赵盼盼,张科平,崔倩,林丹义,许洁. 非小细胞肺癌ALK基因FISH检测出现不典型信号的处理方法. 临床与实验病理学杂志...
TAKEUCHI K,CHOI Y L,TOGASHI Y,et al.KIF5B-ALK,a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer[J].Cell,2007,131(6):1190-1203. H Hatanaka. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer...
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 448, 561–566 (2007). Article CAS PubMed Google Scholar Ou, S. I., Zhu, V. W. & Nagasaka, M. Catalog of 5′ fusion partners in ALK-positive NSCLC circa 2020. JTO Clin. Res. Rep. 1,...
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non-small cell lung carcinoma (NSCLC). Secondary proteins include Echinoderm Microtubule-Associated Protein-Like 4 (EML-4) and TRK-Fusion Gene (TFG). The EML4-ALK fusion protein, which retains ALK tyrosine kinase activity, was confirmed to drive the proliferation and survival of NSCLC ...
参考文献: Li Y ,et al.,Responses to crizotinib and chemotherapy in patients with lung adenocarcinoma harboring a concomitant EGFR mutation and ALK gene rearrangement: A case report and review of the literature. Mol Clin Oncol. 2017 Aug;7(2):173-182 ...
ALK-positive lung cancer is the result of an acquired (not inherited) genetic alteration in the cancer cells, which consists of a fusion between the ALK gene and other genes. The most common of these is called EML4. ALK belongs to a class of genes that encode proteins called kinases. Kina...
[2]. Soda M, Choi Y L, Enomoto M, et al. Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer[J]. Nature, 2007, 448(7153): 561-566.