Anaplastic large cell lymphomas (ALCLs) represent a relatively common group of T-cell non-Hodgkin lymphomas (T-NHLs) that are unified by similar pathologic features but demonstrate marked genetic heterogeneity. ALCLs are broadly classified as being anaplastic lymphoma kinase (ALK)+ or ALK-, based...
ALK-negative anaplastic large cell lymphoma (ALCL), now included as a full entity in the group of mature T- cell neoplasms, is characterized by very large cells with abundant cytoplasm and prominent nucleoli. These cells are strongly positive for CD30 and in more than half of all patients th...
workimages in hematologyLeukemic presentation of a highly aggressive ALK-negativeanaplastic large cell lymphomaDanmei Xu and Kikkeri N. Naresh, Imperial College Healthcare NHS TrustA 69-year-old man presented with cough and constitutional symp-toms (white blood cell [WBC] count: 16.8 3 10 9 /L...
Anaplastic large-cell lymphoma (ALCL) of T- or null-cell lineage, as defined in the revised European-American lymphoma classification, includes a subset of tumors that carry the t(2;5)(p23;q35) resulting in overexpression of anaplastic lymphoma kinase (ALK). Patients with ALK+ ALCL are ...
workimages in hematologySmall-cell pattern of DUSP22 rearranged ALK-negativeanaplastic large-cell lymphoma with leukemic phaseHideki Aarakaki, Okinawa Prefectural Nanbu Medical Center and Children’s Medical Center; and Kennosuke Karube, Universityof the RyukyusA 58-year-old woman presented with genera...
large cell lymphoma (ALCL) is a rare hematological malignancy and a distinct subtype of mature T-cell lymphomas.Anaplastic large cell lymphoma (ALCL) is divided into three subtypes: ALK-positive ALCL,anaplastic lymphoma kinase (ALK)-negative ALCL and primary cutaneous ALCL.Although presenting with ...
large cell lymphoma (ALCL) is a rare hematological malignancy and a distinct subtype of mature T-cell lymphomas.Anaplastic large cell lymphoma (ALCL) is divided into three subtypes: ALK-positive ALCL,anaplastic lymphoma kinase (ALK)-negative ALCL and primary cutaneous ALCL.Although presenting with ...
Anaplastic large-cell lymphoma (ALCL) can be further classified into anaplastic lymphoma kinase-positive (ALK) and ALK-negative types. ALK-negative ALCL is indistinguishable from ALK ALCL by morphology, but lacks ALK translocation or protein expression. Patients with ALK ALCL have an overall better ...
ALK-negative anaplastic large-cell lymphoma demonstrates similar poor prognosis to peripheral T-cell lymphoma, unspecified. R.L. Berge,P.C. Bruin,J.J. Oudejans. Histopathology . 2003R L ten Berge,P C de Bruin,J J Oudejans,G J Ossenkoppele.ALK-negative anaplastic large-cell lymphoma ...
Anaplastic Large Cell Lymphoma, ALK-Negative Presenting in the Rectum: A Case Report and Review of the Literature. Open J Pathol. 2013;3(1):37-40.Komal Galani,Suryakanth R. Gurudu,Longwen Chen,Katalin Kelemen.Anaplastic Large Cell Lymphoma, ALK-Negative Presenting in the Rectum: A Case ...