ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes. Blood. 2014;124(9):1473-1480.Parrilla Castellar ER, Jaffe ES, Said JW, Swerdlow SH, Ketterling RP, Knudson RA, et al. ALK-negative anaplastic large cell lymphoma is a ...
DUSP22、TP63在间变性淋巴瘤激酶(ALK)阴性的间变性大细胞淋巴瘤(ALK negative anaplastic large cell lymphoma,ALK-ALCL)中染色体易位与临床病理特征的关系,应用荧光原位杂交(FISH)技术检测ALK-ALCL病例DUSP22、TP63染色体易位情况;统计分析DUSP22和TP63染色体易位与...
【3】StevenH.Swerdlow,Elias Campo,Stefano A.Pileri.et al.The 2016 revision of the WorldHealth Organization classification of lymphoid neoplasms. BLOOD.2016;127(20):2375-2390. 【4】Abdullgaffar B,SeliemRM.ALK-Negative Anaplastic Large Cell Lym...
Aims: Anaplastic large cell lymphoma (ALCL) is classically considered a clinicopathological entity separate from other nodal mature T-cell lymphomas (TCL). Recently, the anaplastic lymphoma kinase (ALK) protein was shown to identify a subgroup of nodal ALCL with an excellent prognosis, whereas ALK-...
Anaplastic large cell lymphoma, ALK-negative 更新时间:2018-09-30 15:46:00 概述: ALK阴性ALCL是一类CD30阳性T细胞淋巴瘤,其形态学与ALK阳性ALCL不能区分,不表达ALK蛋白,2008WHO列为临时疾病实体,但2017年版WHO已将其确立为正式疾病实体。ALK阴性ALCL必需与原发性皮肤ALCL、霍奇金淋巴瘤及其它具有间变特征或者...
ALK(Anaplastic lymphoma kinase,间变性淋巴瘤激酶)是一个由1620个氨基酸组成的单次跨膜蛋白,其编码基因位于2号染色体。ALK基因重排在非小细胞肺癌(NSCLC)中的发生率为5%~7%,是治疗NSCLC的重要靶点之一。ALK抑制剂的主要作用机制是通过与 ATP 结合位点结合,进而阻断ALK下游信号通路的激活,主要包括PI3K,RAS和JAK三条信...
ALK融合型肺癌是肺癌的一种分子分型,分型意义是为了指导临床诊疗决策。 间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)是一种酪氨酸激酶,在多个肿瘤中都有异常表达。 ALK融合型肺癌是指肺癌患者的ALK基因产生融合,主要包括含有重排的ALK基因或ALK融合蛋白两种情况,主要存在于非小细胞肺癌(NSCLC)中。 不管是ALK基因...
该病例最后诊断间变性淋巴瘤激酶(anaplasticlymphoma kinase,ALK)阴性的间变性大细胞淋巴瘤(anaplastic large cell lymphoma,ALCL) ,即ALK-ALCL。让群里的所有老师感到十分意外并惊喜,意外的是没有人想到这个结果,而惊喜的是大家又一次大饱眼福沈老师的精彩病例,并且可以继续深入学习。根据现有的检查结果及沈老师的分析...
Anaplastic large cell lymphoma of the breast is a rare malignancy associated with prosthetic breast implants. We present a case of a woman with no prior history of breast implants who developed anaplastic lymphoma kinase-1 negative anaplastic large cell lymphoma on a background of a previous benign...
品牌:MedChemExpress (MCE) MCE 国际站:Anaplastic lymphoma kinase (ALK) 靶点描述:间变性淋巴瘤激酶 (ALK) 是胰岛素受体超家族中的一种受体酪氨酸激酶,主要在大脑中表达并与神经元发育和认知有关。 ALK 催化γ-磷酸基团从三磷酸腺苷 (ATP) 转移到底物蛋白上的酪氨酸残基。因此,它催化其底物蛋白上的酪氨酸残基...