ALK-positive large B-cell lymphomaALKMYCplasmablastic lymphomaSTAT3ALK-positive large B-cell lymphoma is an aggressive lymphoid neoplasm characterized by a monomorphic proliferation of immunoblast-like cells expressing a plasmablastic phenotype and carrying ALK rearrangements. MYC rearrangements are frequent ...
ALK-positive diffuse large B-cell lymphoma: report of four cases and review of the literature. Mod Pathol. 2007;20(3):310-9.Reichard KK, McKenna RW, Kroft SH. ALK-positive diffuse large B-cell lymphoma: report of four cases and review of the literature [ J ]. Mod Patho1,2007,20 (...
CLINICO‐PATHOLOGICAL PROFILE AND CMYC IMMUNOREACTIVITY OF ALK POSITIVE LARGE B CELL LYMPHOMA: REPORT OF NINE CASES.Transmembrane activator and CAML interactor (TACI) was identified as a receptor for BAFF and APRIL, two members of TNF ligand family. The significantly lower TACI expression on B ...
Anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma (ALK+LBCL) is a rare subtype of lymphoma defined as a neoplasm of ALK-positive large immunoblast-like B-cells, with occasional plas...doi:10.1080/10428194.2018.1493731Mikiko Ise...
Next-generation ALK inhibitors are highly active in ALK-positive large B-cell lymphoma Blood, Volume 140, Issue 16, 20 October 2022, Pages 1822-1826 Jacob D. Soumerai, Allison Rosenthal, Shannon Harkins, Jessica Duffy, Carmen Mecca, Yingbing Wang, Ravinder K. Grewal, Areej R. El-Jawahri,...
We report detailed clinical and pathologic features of four cases of anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma (ALK-DLBCL), a rare entity with only 29 currently reported cases. This study is the third largest of all reported series. Biopsies from four adult patients aged ...
Anaplastic large cell lymphoma (ALCL), anaplastic lymphoma kinase (ALK)-positive (ALK+ ALCL) is an aggressive CD30-positive T-cell lymphoma that exhibits a chromosomal translocation involving the ALK gene and the expression of ALK protein. No particular risk factor has been clearly identified for...
Xalkori is indicated for the treatment of pediatric patients 1 year of age and older and young adults with relapsed or refractory, systemic anaplastic large cell lymphoma (ALCL) that is ALK-positive. The safety and efficacy of Xalkori have not been established in ...
Anaplastic large cell lymphoma CT: Computed tomography DLBCL: Diffuse large B cell lymphoma EATL: Enteropathy-associated T-cell lymphoma EBER: Epstein-Barr virus (EBV)-encoded small RNA GI: Gastrointestinal HL: Hodgkin’s lymphoma IHC: Immunohistochemistry ISH: In situ hybridization MALT...
Anaplastic lymphoma kinase (ALK) is a member of the insulin receptor protein-tyrosine kinase superfamily and was first discovered in anaplastic large-cell lymphoma (ALCL). ALK alterations, including fusions, over-expression and mutations, are highly associated with cancer initiation and progression. Thi...