( N APD H oxi dase,N O X) 亚基及其调控的磷脂酰肌醇一3一羟激酶/蛋白激酶( phosphati dyl3-ki nase/Akt,P13K/Akt) 、P38丝裂原活化蛋白激酶( P38 m i togen- acti vated protei n ki nase,P38M APK) 信号通路目的观察熊果酸( ursol i c aci d,U A) 对大鼠活化型肝星状细胞一6( hepati...
并初步阐明萎缩骨骼肌恢复速率减慢的原因.主要研究结果为: 1)特定骨骼肌收缩模式可增加p38磷酸化水平,对ERK与Akt磷酸化水平无影响5 min 10 %DC(duty cycle负荷率)和5 min 1 %DC的收缩模式可分别使p38的磷酸化较对照组增加30 %和34 %,是激活p38的适宜刺激.但这两种刺激模式对ERK和Akt的磷酸化水平没有影响....
P38AKT通路调控骨髓间充质干细胞在不同空间结构纳米纤维环支架中的定向分化
P38 MAPK信号传导途径示意图 热度: InterplaybetweenAktandp38MAPKpathwaysintheregulationofrenal tubularcellapoptosisassociatedwithdiabeticnephropathy MadhaviJ.Rane, 1,2,4 *YeSong, 1,4 *ShunyingJin, 1 *MichelleT.Barati, 1 RuiWu, 1 HinaKausar, ...
联合应用p38MAPK抑制剂对降低结肠癌阿霉素耐药性的影响 目的:探讨p38 MAPK抑制剂通过Akt(蛋白激酶B)有关的信号途径对结肠癌细胞阿霉素(Doxorubicin)化疗敏感性的影响.方法:应用阿霉素(Dox)和p38 MAPK特异性抑制剂SB203580及... 李金鹏,周巍,张军,... - 《世界华人消化杂志》 被引量: 6发表: 2012年 p38MAPK...
目的:研究葛根素(PRN)是否通过Akt/p38途径协同三氧化二砷(As2O3)促进人胶质瘤细胞的凋亡.方法:MTT检测细胞的存活率,流式细胞仪(FCM)技术检测细胞的凋亡状态,蛋白免疫印迹(Immunoblotting)检测细胞phosphorylated Akt和p38-MAPK,Cleaved Caspase-3蛋白的表达,PCR检测Caspase-3的mRNA的表达.结果:PRN协同As2O3降低人胶质...
Hepatocellular carcinoma (HCC), a common liver malignancy worldwide, has high morbidity and mortality. β-Thujaplicin, a tropolone derivative, has been used in some health-care products and clinical adjuvant drugs, but its use for HCC is unknown. In this
Our data suggest that R1881 reduced the proliferation rate of HUVEC through activating the AR/cSrc/AKT/p38/ERK/NF魏B pathway, subsequently up-regulating p53 expression, which in turn increased the levels of p21 and p27 protein, hence decreasing the activities of cyclin-dependent kinase 2 (CDK...
AktP38 MAPKBetanin, a water-soluble nitrogenous pigment, is found to exert various health benefits including anti-oxidative, anti-inflammatory, anti-hyperglycemic and cardioprotective effects. However, the roles of betanin in platelet function is completely unknown. In the present study we investigated...
(P0.05).Western blot结果显示,高良姜素+阿帕替尼组Bcl-2相关X蛋白(Bax),磷酸化蛋白激酶B(p-Akt),磷酸化丝裂原活化蛋白激酶(p-p38)蛋白表达明显高于20 mg/L阿帕替尼组,B淋巴细胞瘤-2(Bcl-2)蛋白明显低于20 mg/L阿帕替尼组(P0.05).结论高良姜素可能通过抑制PI3K/Akt和激活p38-MAPK信号通路增强阿帕替尼...