(2004). Role of Akt/protein kinase B in the activity of transcriptional coactivator p300. Cell. Mol. Life Sci. 61, 1675-1683. doi: 10.1007/s00018-004-4103-9Chen J, Halappanavar SS, St-Germain JR, Tsang BK, Li Q. Role of Akt/protein kinase B in the activity of transcriptional ...
Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity. Mol Cell Biol. 2005;25(15):6592–602. Article CAS Google Scholar Spangle JM, Roberts TM, Zhao JJ. The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer. Biochim...
human Akt1 is recruited to the plasma membrane [1,2] and phosphorylated by PDK1 at T308 within its catalytic domain, which is critical for Akt kinase activation. Human Akt1 is also phosphorylated by a protein complex formed by serine/threonine kinasemTORC2(mTOR complex 2), consisting of mammal...
acetylation, and K63-linked ubiquitination, the latter targeting AKT for lysosomal or proteasomal degradation (although it may also activate AKT, as alluded to above). Each of these post-translational modifications is subject to regulation by different proteins. De-SUMOylation can occur in the ...
in the hippocampus. Epigenetic analyses reveal that histone modifications, but not DNA methylation, underlie exon-specific transcription of theBdnfgene induced by leptin. This is mediated by stimulation of AKT signaling, which in turn activates histone acetyltransferase p300 (p300 HAT), leading to chan...
ING5 interacts with p300 and p53 via a zinc finger domain to promote apoptosis [50]. ING5 inhibition induced lung tumor cell invasion through promotion of the EGFR/PI3K/AKT mediated EMT process. ING5 had inhibitory role on EGFR/PI3K/AKT axis by p-AKT down regulation [51]. Sirtuin-1 (...
Ultrasound induces cyclooxygenase-2 expression through integrin, integrin-linked kinase, Akt, NF- κ B and p300 pathway in human chondrocytes. Cellular Signalling . 2007; 19 (11):2317–2328.Hsu HC, Fong YC, Chang CS, Hsu CJ, Hsu SF, Lin JG, Fu WM, Yang RS, Tang CH (2007) Ultrasound...
[133]. Hence, the effect of BAP1 on Akt activity is inconclusive. Except for polyubiquitination, acetylation of Akt1 at lysine 14/20 by histone acetyltransferase P300 and lysine acetyltransferase 2B inhibits Akt activation [134]. Deacetylation of Akt1 by sirtunin 1 restores the activity of Akt1 ...
p300Akt1humanS1834S1834MLRRRMAsMQRTGVV16024795,11116148Transcriptional co-activator; phosphorylation can either activate or suppress transcriptional activity depending on cell type and physiological stimuli p47phoxAkt1humanS304, S328S304, S328GAPPRRssIRNAHSI, QDAYRRNsVRFLQQR12734380A component of the phago...
Acetylation is another lysine modification that can negatively regulate Akt activity [70]. It has been demonstrated that the level of Akt acetylation induced by IGF-1 or insulin inversely correlates with Akt phosphorylation and signaling [70]. p300 and p300/CBP-associated factor (PCAF) are the ac...