High PD-L1 expression drives glycolysis via an Akt/mTOR/HIF-1 alpha axis in acute myeloid leukemiaprogrammed cell death 1 ligand 1glycolysisacute myeloid leukemiametabolismsignaling pathwayAcute myeloid leukemia (AML) is a hematological malignancy derived from immature myeloid cells, which have the ...
1Yun1Ho1Jin1Guang1Yu1Li1Liang1chang1Yan1EBSCO_AspPlos OneChoi Y H, Jin G Y, Li L C, et al. Inhibition of protein kinase C delta attenuates allergic airway inflammation through suppression of PI3K/Akt/mTOR/HIF-1 alpha/VEGF pathway [J]. PLoS One, 2013, 8(11): e81773....
Taken together, this work reports that HIF-1 alpha promotes viability and migration of activated B cell-like cells under hypoxia, which might involve the transcription of CXCR4 and the activation of the AKT/mTOR pathway. The finding may provide novel lights in the management of DCBCL....
Dayan F, Bilton RL, Laferriere J, Trottier E, Roux D, Pouyssegur J, Mazure NM. Activation of HIF-1alpha in exponentially growing cells via hypoxic stimulation is independent of the Akt/mTOR pathway. J Cell Physiol 2009;218:167-174...