据报道,核因子kappa-B(NF-κB)信号可调控小胶质细胞的极化,而肿瘤坏死因子受体相关因子6(TRAF6)在此过程中可通过泛素化激活NF-κB通路。芳香烃受体(AHR)通过TRAF6参与调节NF-κB信号的激活点3。 有研究表明,慢性炎症和神经退行性病变贯穿CSVD的整个病理过程4。既往研究显示,C.EDA在缺血性卒中动物模型中可发挥抗炎...
Nuclear factor kappa B (NF-κB) and aryl hydrocarbon receptor (AhR) signaling pathways are known to be expressed and play an important role in the lung. However, the link between Pb lung toxicity and NF-κB and/or AhR pathways remains unclear. ...
Baccam M, Woo SY, Vinson C, Bishop GA: CD40-mediated transcriptional regulation of the IL-6 gene in B lymphocytes: involvement of NF-kappa B, AP-1, and C/EBP. J Immunol. 2003, 170: 3099-3108. Article CAS Google Scholar Zerbini LF, Wang Y, Cho JY, Libermann TA: Constitutive activ...
YS-1617B Anti-NF-κBp50(p50 NF-kappa B;p50NFKB) 细胞核因子50/κ基因结合核因子50抗体YS-1618B Anti-NGF-R/p75NTR/CD271(p75 Neurotrophin R) 神经生长因子受体抗体YS-1619B Anti-NGF-β 神经生长因子-β抗体YS-1620B anti-NGN3(neurogenin 3; Neurog3) 神经元素3抗体YS-1621B Anti-NGX6 (...
(CREB-Binding Protein)/p300). In addition, AHR is also known to interact with signaling pathways that are mediated by ESR (Estrogen Receptor) and other Hormone receptors, Hypoxia, NF-KappaB (Nuclear Factor-Kappa-B) and Rb (Retinoblastoma) protein (Ref.1 2). Normally, AHR exists in a ...
ahr信号传递的替代途径也进行了描述,诸如结合至视网膜母细胞瘤蛋白,雌激素受体(er),转录因子e2f1和nfκb途径亚单元rela和relb。ahr也可作为泛素连接酶。因此,通过ahr的信号传递包含多种途径,包括组成型和非组成型ahr信号传递通路或信号传递活性,本文对这些术语进行了定义。 如本文所用,“组成型ahr信号传递”是指一...
Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NF kappa B ... Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFκB and ...
致癌基因24卷:7869-7881页)16.MinjC.,S.F.Eddy,D.H.Sherr,andG.E.Sonenshein.2008.NF-kappaBandepithelialtomesenchymaltransitionofcancer.JCellBiochem104:733-744.敏,C.,S.F.埃迪,D.H.雪儿,和G.E.索南沙因.2008年.癌症的NF-kB和上皮细胞间质样转化.细胞生物化学杂志104卷:733-744页)17.HahnjM.E...
(nuclear factor kappa B,NF-κB)信号通路的持续性异常活化是导致AHR在HTLV-1阳性T细胞中恒定高表达的重要原因;(4)病毒蛋白Tax可以通过激活NF-κB来提高AHR的表达.以上的研究结果表明:NF-κB信号通路的持续性异常活化为AHR在HTLV-1阳性T细胞中的恒定高表达奠定了基础,这赋予了HTLV-1可以根据微环境中AHR配体的水平...
Cytokines produced by immune cells and inflammatory synovial fibroblasts including Interleukin-17 (IL-17), Interleukin-6 (IL-6), and receptor activator of nuclear factor kappa-Β ligand (RANKL)18 also showed no difference between the two RA groups (Fig. 1c and Supplementary Fig. 1a). We ...