Specifically, SPD's binding to AhR plays a crucial role in modulating the inflammatory response and cellular pyroptosis by inhibiting both the AhR/NF-kB and NLRP3/caspase-1/GSDMD signaling pathways. Furthermore, the knockdown of AhR was found to negate the beneficia...
Kolasa E, Houlbert N, Balaguer P, Fardel O(2013)AhR- and NF-kB-dependent induction of interleukin-6 by co-exposure to the environmental contaminant benzanthracene and the cytokine tumor necrosis factor-a in human mammary MCF-7 cells. Chem Biol Interact. 203 (2): 391-400. 82. Jarvis IW...
Synergistic effects of benzo[a]pyrene and aromatic amines on AhR- and NFkB-signal transduction in urothelial cellsdoi:10.1016/j.toxlet.2011.05.815K.HerbstandP.H.RoosSDOSToxicology Letters