Kolasa, E., et al., AhR- and NF-kappaB-dependent induction of interleukin-6 by co-exposure to the environmental contaminant benzanthracene and the cytokine tumor necrosis factor-alpha in human mammary MCF-7 cells. Chem Biol Interact, 2013. 203(2): p. 391-400....
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Specifically, SPD's binding to AhR plays a crucial role in modulating the inflammatory response and cellular pyroptosis by inhibiting both the AhR/NF-kB and NLRP3/caspase-1/GSDMD signaling pathways. Furthermore, the knockdown of AhR was found to negate the beneficia...
Synergistic effects of benzo[a]pyrene and aromatic amines on AhR- and NFkB-signal transduction in urothelial cellsdoi:10.1016/j.toxlet.2011.05.815K.HerbstandP.H.RoosSDOSToxicology Letters