Endogenous cellular DNA is a contributing factor to aseptic inflammation, which occurs in the absence of pathogenic infection. Additionally, it is associated with the development of many chronic diseases, including cardiovascular disease and neurodegenerative disorders.47Aseptic inflammation is an important m...
After it was first reported in Wuhan, China in December 2019, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19) has become the worst pandemic of the twenty-first century. As of July 11, 2021, 183 ...
et al. Immunotherapies for Alzheimer’s disease—a review. Vaccines https://doi.org/10.3390/vaccines10091527 (2022). Pecchi, E. et al. Induction of nerve growth factor expression and release by mechanical and inflammatory stimuli in chondrocytes: possible involvement in osteoarthritis pain. ...
npj Aging and Mechanisms of Disease is an online open access journal that provides a forum for the world’s most important research in the fields of aging and aging-related disease. The journal publishes papers from all relevant disciplines, encouraging those that shed light on the mechanisms beh...
Ischemic stroke is a complex disease with a growing multitude of risk factors. Aging is the principal risk factor for ischemic stroke, such that stroke occurs more often, and is more severe, in older demographics. Furthermore, among this population, stro
1. Hou, Y. et al. Ageing as a risk factor for neurodegenerative disease. Nat Rev Neurol 15, 565-581 (2019).2. Hong, S., Dissing-Olesen, L. & Stevens, B. New insights on the role of microglia in synaptic pruning in health and disease. Curr Opin Neurobiol 36, 128-34 (2016).3....
disease group(n=306),single-vessel group(n=211),double-(n=126) and multi-Vessel group(n=90) were compared referred for angiography.Quantitative comparison of age and risk factors were made among patients with 4 ranges of Gensini's score corresponding to quartile cut points.The impact of age...
Dietary interventions, cardiovascular aging, and disease: animal models and human studies. Circ Res. 2016;118(10):1612–25. Article CAS PubMed Google Scholar Rubinek T, Modan-Moses D. Klotho and the growth hormone/insulin-like growth factor 1 axis: novel insights into complex interactions. ...
(>95%), 46.2% were male, aged 57 ± 8-year-old, with a substantial prevalence of hypertension (54%) and some prevalence of coronary heart disease (3–5%) and diabetes (3–5%). In the first group, baseline PHQ-4 scores averaged 1.58 ± 2.08. Based on PHQ-4 scores and ...
cerebrovascular disease outcomes [170,171], suggesting a bidirectional relationship. Neurodegeneration Aging is the strongest risk factor for dementia [172], a collective term for cognitive impairment negatively affecting independent functional activities. Alzheimer’s disease (AD), the most common dementia...