Endogenous cellular DNA is a contributing factor to aseptic inflammation, which occurs in the absence of pathogenic infection. Additionally, it is associated with the development of many chronic diseases, including cardiovascular disease and neurodegenerative disorders.47Aseptic inflammation is an important m...
et al. Immunotherapies for Alzheimer’s disease—a review. Vaccines https://doi.org/10.3390/vaccines10091527 (2022). Pecchi, E. et al. Induction of nerve growth factor expression and release by mechanical and inflammatory stimuli in chondrocytes: possible involvement in osteoarthritis pain. ...
认为该研究非常有价值，增进了人们对小胶质细胞老龄化及其如何影响记忆的理解（This represents a highly relevant paper that improves our understanding of microglial aging and its impact on memory）。
npj Aging and Mechanisms of Disease is an online open access journal that provides a forum for the world’s most important research in the fields of aging and aging-related disease. The journal publishes papers from all relevant disciplines, encouraging those that shed light on the mechanisms beh...
Impact Factor 6.4 Submit Messages Carousel Explores the mechanisms of central nervous system aging and age-related neural disease The third most-cited journal in the field of geriatrics and gerontology, with a focus on understanding the mechanistic processes associated with central nervous system aging....
disease group(n=306),single-vessel group(n=211),double-(n=126) and multi-Vessel group(n=90) were compared referred for angiography.Quantitative comparison of age and risk factors were made among patients with 4 ranges of Gensini's score corresponding to quartile cut points.The impact of age...
Journal Impact Factor 3.3 (2023) 5-year Journal Impact Factor 3.4 (2023) Submission to first decision (median) 7 days Downloads 227,145 (2023) Calls for papers Collection Frailty and Neurodegenerative Disease The Journal of Frailty & Aging (JFA) is looking for outstanding articles on Frailty ...
因此,clearing p16 -positive senescent cells in Ldlr / mice led to reduce fatty streaks in early stage and reduced plaque burden in late stages of the disease 。 V. SENESCENT CELLS IN CANCER A. Cell-Autonomous Regulation of Senescence in Cancer 1. Oncogene-induced senescence The ...
(>95%), 46.2% were male, aged 57 ± 8-year-old, with a substantial prevalence of hypertension (54%) and some prevalence of coronary heart disease (3–5%) and diabetes (3–5%). In the first group, baseline PHQ-4 scores averaged 1.58 ± 2.08. Based on PHQ-4 scores and ...
cerebrovascular disease outcomes [170,171], suggesting a bidirectional relationship. Neurodegeneration Aging is the strongest risk factor for dementia [172], a collective term for cognitive impairment negatively affecting independent functional activities. Alzheimer’s disease (AD), the most common dementia...