BCR-ABL, FLT3-ITD, and differentiation-associated SIRT7-expression in general were positively regulated by C/EBPα, -β, and -ε binding to two different C/EBP-binding sites within the SIRT7 promoter. SIRT7 is important in human hematopoietic cell aging and longevity. It might act as tumor...
After chronic and prolonged replication, cell senescence may occur as a natural part of the disc aging process, but can potentially be accelerated by growth factor deficiency, oxidative accumulation, and inflammatory irritation. While acute disc injury, excessive mechanical overloading, diabetes, and ...
and informative. The emerging field of aging research has created a need for dissemination of this type of information, especially in mammalian model organisms and humans. PBA is interdisciplinary in nature and covers all aspects of pathology of aging related to disease phenotypes including cancer, ...
Aging is a major risk factor for numerous chronic diseases. Vaccination offers a promising strategy to combat these age-related diseases by targeting specific antigens and inducing immune responses. Here, we provide a comprehensive overview of recent advances in vaccine-based interventions targeting thes...
Aging happens to all of us as we live. Thanks to the improved living standard and discovery of life-saving medicines, our life expectancy has increased substantially across the world in the past century. However, the rise in lifespan leads to unprecedent
Objective: White matter hyperintensity (WMH) volume is a neuroimaging marker of lesion load related to small vessel disease that has been associated with cognitive aging and Alzheimer's disease (AD) risk. Method: The present study sought to examine whether regional WMH volume...
(2011). The impact of urbanization on CO2 emissions: Evidence from developing countries. Ecological Economics, 70, 1344–1353. Article Google Scholar Menz, T., & Kuhling, J. (2011). Population aging and environmental quality in OECD countries: Evidence from sulfur dioxide emissions data. ...
Revising two-point discrimination assessment in normal aging and in patients with polyneuropathies. J Neurol Neurosurg Psychiatry. 2008;79(7):832-834. doi:10.1136/jnnp.2007.139220PubMedGoogle ScholarCrossref 27. Calhoun EA, Welshman EE, Chang CH, Lurain JR, Fishman DA, ...
Stress resistance characters have been associated in many studies with fitness related traits (e.g. longevity, fecundity, body mass), agingper se(senescence) and colonization success and thus have great ecological and evolutionary significance. For example, selection for SR increased longevity and redu...
The population of rhesus macaques (Macaca mulatta) on Cayo Santiago, Puerto Rico26, provides a unique opportunity to examine the impact of age on male reproductive output for several reasons. First, the long-term database for this population includes the age of each individual and detailed record...