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另外,两者拥有相同的抗原结合表位和相似的亲和力。 Afucosylated antiboy:Obinutuzumab Obinutuzumab的人源化和糖基化改造发表在2010年的Blood杂志。GA101来源于鼠源抗体B-ly1,在人源化的过程中重链使用的是VH1-10和JH4人种系序列,轻链使用的是VK-2-40和JK4人种系序列。GA101转染到过表达β-1,4-N-乙酰氨基葡萄...
The structures reveal a unique type of interface consisting of carbohydrate–carbohydrate interactions between glycans of the receptor and the afucosylated Fc. ... C Ferrara,S Grau,Christiane Jaeger,... - 《Proc Natl Acad Sci U S A》 被引量: 502发表: 2011年 Pharmacokinetics of IgG1 monoclonal...
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[0099] 根据本发明的afucosylated抗CCR5抗体可在一种糖修饰的宿主细胞中表达,所 述细胞被改造为表达至少一种编码具有GnTIII活性的多肽的核酸,任选的还表达编码具 有ManII活性的多肽的核酸,用于以根据本发明的量岩藻糖基化根据本发明的抗体的Fc 区。在一个实施方案中,具有GnTIII活性的多肽为融合多肽。可选的可...
专利名称：抗CCR5的afucosylated抗体及其用途 专利类型：发明专利 发明人：J·奥尔,A·贝尔松,M·布兰特,J·M·洛拉,S·里斯,D·C·博里 申请号：CN200980102290.8 申请日：20090113 公开号：CN101918451A 公开日：20101215 专利内容由知识产权出版社提供 摘要：与CCR5结合并在Asn297用糖链糖基化的抗体，所述抗体...
AFUCOSYLATED ANTI-FGFR2IIIB ANTIBODIES 专利名称：AFUCOSYLATED ANTI-FGFR2IIIB ANTIBODIES 发明人：HARDING, Thomas,PIERCE, Kristen,PATIL, Namrata,BRENNAN, Thomas,HAMBLETON,Julie 申请号：EP14752705.5 申请日：20140731 公开号：EP3027651A1 公开日：20160608 专利内容由知识产权出版社提供 摘要：The present ...
摘要 Provided is an afucosylated monoclonal antibody. The monoclonal antibody is a human IgG antibody and has an afucosyla... 收藏 全部来源 求助全文 掌桥科研 相似文献 An afucosylated anti-CD20 monoclonal antibody with greater antibody-dependent cellu...
Provided is an afucosylated monoclonal antibody. The monoclonal antibody is a human IgG antibody and has an afucosylated sugar chain structure at a heavy-chain sugar chain binding site. Also provided are application of the monoclonal antibody in the preparation of antineoplastic drugs, and a compositi...
Figure 1: Demonstration that an afucosylated antibody produced from the WuXiaADCCPLUSTMcell line exhibits significantly enhanced ADCC activity Removal of fucose on the N-glycosylation site is an efficient and cost-effective way to enhance ADCC activity and...