Afucosylated antibodies against CCR5 and their useBe incorporated in Asn297 with the glycosylated antibody of sugar chain with CCR5 knot, described antibody is characterised in that, in described sugar chain be 65% or lower Fucose amount in anti-inflammatory therapy, have improved performance....
WuXiaADCCPLUSTMis designed to meet the market need for improved antibody therapeutic efficacy by producing afucosylated antibodies with the ability to increase antibody-dependent cell-mediated cytotoxicity (ADCC), providing diverse bioprocessing solutions for gl...
11. Co MS, Queen C. Humanized antibodies for therapy. Nature. 1991 Jun 6;351(6326):501-2. doi: 10.1038/351501a0. PMID: 2046753. 12. Wu TT, Kabat EA. An analysis of the sequences of the variable regions of Bence Jones proteins and myeloma light chains and their implications for ant...
AFUCOSYLATED ANTI-FGFR2IIIB ANTIBODIES 专利名称：AFUCOSYLATED ANTI-FGFR2IIIB ANTIBODIES 发明人：HARDING, Thomas,PIERCE, Kristen,PATIL, Namrata,BRENNAN, Thomas,HAMBLETON,Julie 申请号：EP14752705.5 申请日：20140731 公开号：EP3027651A1 公开日：20160608 专利内容由知识产权出版社提供 摘要：The present ...
Antibodies have been employed for decades as a 'magic bullet' against specific targets for diagnosis or therapy. Historically, monoclonal antibodies were produced by hybridomas. However, advances in the field have allowed for the design and production of antibodies with......
During antibody dependent cell cytotoxicity (ADCC) the target cells are killed by monocytes and natural killer cells. ADCC is enhanced when the antibody heavy chain's core N-linked glycan lacks the fucose molecule(s). Several strategies have been utilized to generate fully afucosylated antibodies. ...
3.Kanda, Y., et al., Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types. Glycobiology, 2007. 17(1): p. 104-18. ...
Provided are methods for producing afucosylated antibodies, the afucosylated antibodies and composition thereof and cells for producing antibodies. The method comprises introducing a nucleic acid encoding at least one modified enzyme of the fucosylation pathway to a host cell to produce the afucosylated ...
Provided methods for producing an afucosylated antibody, the afucosylated antibodies and composition thereof, and cells for producing antibodies. The method comprises introducing a nucleic acid encoding at least one modified enzyme of the fucosylation pathway to a host cell to produce the afucosylated ...
during persistent LCMV infection required increased levels of antibody bound to target cells or use of afucosylated antibodies with increased affinity for Fcγ... Andreas,Wieland,O Alice,... - 《Science Immunology》 被引量: 0发表: 2018年 Unique carbohydrate–carbohydrate interactions are required for...