mRNA Metabolism in Cardiac Development and Disease: Life After Transcriptiondoi:10.1152/PHYSREV.00007.2019Chen GaoYibin WangAmerican Physiological Society
state or clustering of the population of PVN CRF cells in the developing mouse, we performed the same cluster analysis on control cells only and determined that segregation of PVN CRF cells into several biologically distinct clusters was not driven by ELA-induced changes to transcription (Figure ...
FFPE-stored tissue suffers RNA degradation from the 5′ end and yields limited amounts of RNA of acceptable quality [7]. Especially the chemical alteration of mRNA through formalin fixation can hamper reverse transcription to c-DNA and can consequently compromise the interpretation of RNA-sequencing...
Sleep deprivation impacts protein synthesis and gene regulation through many mechanisms including alterations to epigenetic regulation, transcription, and mRNA processing11,12,13,14,15,16,17,18,19. Estimates suggest that up to 10% of cortical transcripts are regulated with sleep/wake cycles, particular...
The HBV life cycle is complex, including processes, such as viral entry, cccDNA formation, transcription, replication, assembly, secretion, and integration (Figure 1). HBV enters hepatocytes from the basolateral (sinusoidal) membrane, where the viral receptor, sodium taurocholate cotransporting ...
(FDR < 5%); miR-7859 was not included in existing databases for human species. The top enriched GO terms were associated to metabolic processes, transcription factor binding, response to stimulus, cell cycle and protein kinase binding. GO terms linked to vesicle-mediated transport, ubiquitin...
Previously, RNA analysis was widely used to study the pathophysiological mechanisms underlying TBI; however, the relatively low correlation between the transcriptome and proteome revealed that RNA transcription abundance does not reliably predict protein abundance, which led to the emergence of proteomic ...
and CAT can scavenge excess free radicals and thus reduce the damage to plants from stress. Our study found that the transcription level of POD and the metabolism of gibberellin in rice seedlings were regulated to some extent after stress. As shown inFigure 10, a total of eight genes involved...
The cell-type-associated gene list consisted of five brain cell types, including neurons, astrocytes, oligodendrocytes, microglia, and endothelial cells, and is based on a previously published brain transcription analysis [56,57]. The gene universe (i.e., the gene’s background set for the ...
and then review the status of survivin cancer therapeutics, which is classified into five categories: (i) survivin-partner protein interaction inhibitors, (ii) survivin homodimerization inhibitors, (iii) survivin gene transcription inhibitors, (iv) survivin mRNA inhibitors and (v) survivin immunotherapy...