American Journal of PhysiologyIzumizaki M, Tamaki M, Suzuki Y, Iwase M, Shirasawa T, Kimura H, and Homma I. The affinity of hemoglobin for oxygen affects ventilatory responses in mutant mice with Presbyterian hemoglobinopathy. Am J Physiol Regul Integr Comp Physiol 285: R747-R753, 2003....
During a sickle cell crisis, deoxygenated sickle hemoglobin (deoxyHbS) polymerizes to form fibers in red blood cells (RBCs), causing the cells to adopt “sickled” shapes. Using small molecules to increase the affinity of Hb for oxygen is a potential approach to treating sickle cell disease, ...
Background: A computational proteomic analysis suggested that SARS-CoV-2 might bind to hemoglobin (Hb). The authors hypothesized that this phenomenon could result in a decreased oxygen (O 2 ) binding and lead to hemolytic anemia as well. The aim of this work was to investigate whether the a...
(19666). The effect of hemolysis upon the oxygen affinity of hemoglobin in the Atlantic (Salmo salar) and landlocked salmon (Salmo salar sebago), Jf. Fish. Res. Bd Can. 23, 1575-80.BLACK, E. C.; TUCKER, H. H.; KIRKPATRICK, D. The effect of hemolysis upon the oxigen affinity of ...
of Physicians and Surgeons, globin molecular structure can produce rapid and Columbia Univ., New York (introduced by profound changes in the organization of hemoglobin John C.Sinclair). into gels or crystals. The effect of DPG on the affinity of hemoglobin for oxygen, expressed as P50 (the PO...
of Physicians and Surgeons, globin molecular structure can produce rapid and Columbia Univ., New York (introduced by profound changes in the organization of hemoglobin John C.Sinclair). into gels or crystals. The effect of DPG on the affinity of hemoglobin for oxygen, expressed as P50 (the PO...
The influence of 2,3-diphosphoglycerate concentration (DPG) on hemoglobin-oxygen affinity (P50) in whole blood from adults and newborns has been studied. In blood from adults a decrease in DPG of 0.61 mol DPG/mol Hb is associated with a decrease in P50 of 13 mm Hg. In samples from newb...
Relative affinity of hemoglobin S and hemoglobin A for carbon monoxide and oxygen. The relative affinity constants of hemolysates from individuals with hemoglobins A, S, or AS have been measured at 37 and 26 掳 C. Observed values of all h... Rodkey F Lee,O'Neal John D,Collison Harold ...
As a typical compensatory reaction one might expect changes in oxygen affinity of hemoglobin. Therefore position (standard half saturation pressure P50st) and slope (Hill's n) of the O2 dissociation curve as well as the Bohr coefficients (BC) for CO2 and lactic acid were determined in blood ...
The recent reports of the effect of 2,3-diphosphoglycerate (2,3-DPG) on hemoglobin affinity for oxygen suggested that this substance may play a role in man's adaptation to acidosis and alkalosis.A study of the effect of induced acidosis and alkalosis on the oxyhemoglobin dissociation curve of...