The influence of haemoglobin affinity for oxygen on tumour radiosensitivity. Br J Cancer 1987; 55:487-91.Hirst, D. G., and Wood, P. J. The influence of haemoglobin affinity for oxygen on tumour radiosensitivity. Br. J. Cancer, 55: 487-491, 1987....
Appropriate control of the affinity of haemoglobin for oxygen is fundamental to the efficient oxygenation of our tissues. Important modifiers of this relationship are pH, CO2 concentration and the intraerythrocytic level of 2,3-diphosphoglycerate (2,3-DPG). We have studied the influence of haemoglob...
AbstractVoxelotor is a small molecule that reduces the polymerization of sickle hemoglobin by increasing its affinity for oxygen. In patients with sickle cell anemia, it has been postulated that increasing hemoglobin‐oxygen affinity could limit oxygen offloading from hemoglobin, causing an increase in ...
the purified haemoglobin had too high an affinity for oxygen and too short an intravascular half-life. The HBOCs currently in development have been engineered to have a reduced affinity for oxygen (mimicking the effects of 2, 3 diphosphoglycerate) and an extended circulation time. Preventing haemo...
We conclude that glycosylated haemoglobins, known to have an increased affinity for oxygen when purified and in diluted solutions, do not play a significant role in the oxygen affinity pattern of diabetics at the concentrations normally found in vivo. 展开 关键词: Glycosylated haemoglobins HbA1c ...
The invention relates to a method for the preparation of artificial oxygen carriers from chemically cross-linked hemoglobins with improved functional properties, chemically unreactive effectors of the oxygen affinity being added to the h... W Barnikol - US 被引量: 202发表: 2004年 Nuclear magnetic...
1. 1.1. The respiratory pigment of the pogonophore Siboglinum ekmani has an extraordinarily high affinity for oxygen, the p50 being 0.085 mm Hg (11.3 N m2) at pH 6.5 and 20°C.2.2. The pigment is an unstable plasma haemoglobin which is r... HJ Yuasa,T Furukohri,T Suzuki,... 被...
Haemoglobin is having maximum affinity with View Solution Haemoglobin is not found in View Solution Knowledge Check Question 1 - Select One Haemoglobin is the oxygen-carrying pigment of : Aleucocytes Berythrocytes Costeocytes DthrombocytesSubmit Question 2 - Select One Haemoglobin is specifically ...
The low oxygen affinity of many fish haemoglobins at low p H is suggested to be due to the replacement by serine of the reactive cysteine F9尾 found in mam... MF Perutz,M Brunori - 《Nature》 被引量: 336发表: 1982年 Crystallographic analysis of mutant human haemoglobins made in Escheri...
A dose-dependent increase in wholeblood oxygen affinity was observed, resulting from the action of BW12C in stabilising the oxy-conformation of haemoglobin and causing a left shift of the oxygen saturation curve. At the highest dose given (20 mg/kg bodyweight), up to 23% of haemoglobin was...