We discuss clinical experience with several classes of drugs that are currently used to treat cancer pain: 1) nonsteroidal anti-inflammatory drugs, with emphasis on cyclooxygenase-2 inhibitors; 2) opioid analgesics, with specific emphasis on methadone and its newly recognized value in cancer pain; ...
Pain and Nociception: Mechanisms of Cancer-Induced Bone Pain Cancer pain, especially pain caused by metastasis to bone, is a severe type of pain, and unless the cause and consequences can be resolved, the pain will b... S Falk,AH Dickenson - 《Journal of Clinical Oncology Official Journal ...
Neoplasm Metastasisanalgesics non-narcoticanalgesics opioidCancer related pain may be due to the malignant disease itself, or subsequent to treatments, such as surgery, chemotherapy or radiation therapy. The pathophysiology of pain due to cancer may be complex and include a variety of nociceptive, ...
摘要: Pain continues to be a common complication of cancer.It severely impacts the quality of life of cancer patients and deteriorates their believes to anti-cancer therapies.This article reviews recent research in the relief of cancer pain.关键词:...
With the gradual demographic shift toward an aging and obese society, an increasing number of patients are suffering from bone and cartilage injuries. However, conventional therapies are hindered by the defects of materials, failing to adequately stimula
with emphasis on cyclooxygenase-2 (COX-2) inhibitors; 2) opioid analgesics, with specific emphasis on methadone and its newly recognized value in cancer pain; 3) ketamine, an antagonist at N-methyl d-aspartate (NMDA) receptors; and 4) bisphosphonates, used for pain resulting from bone metasta...
The gene microarray technique is another advance for detecting micrometastasis. The gene analysis also can help understanding the biological characteristics of the primary tumor. The treatment of bone metastases in lung cancer is various, including systemic and local therapeutic means. Surgery is often ...
N4-acetylcytidine (ac4C) is a highly conserved chemical modification widely found in eukaryotic and prokaryotic RNA, such as tRNA, rRNA, and mRNA. This modification is significantly associated with various human diseases, especially cancer, and its forma
The study of pain in the cancer patient offers a unique opportunity to use clinical observations to advance biologic knowledge. The cancer patient unfortunately represents the experimental model of pain. This group of heroic patients can help teach us the physiologic and psychologic differences between...
In an advanced stage, PCa may cause bone pain, difficulty in urination and generalized infection or renal failure (Litwin and Tan, 2017; American Cancer Society, 2023). A thorough anamneses and physical examination are essential when assessing men with urinary symptoms (Willacy, 2021). When ...