The involvement of PARP proteins in DNA damage detection and repair, telomere maintenance, and stress responses and recovery gives hope for the use of PARP inhibition as a means for selective 'next generation' therapies for cancer, as well as stress-related diseases that exhibit pro-inflammatory ...
refers to the standard error of means. The sample size was not predetermined. Reporting summary Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article.Data availability All data are available in the main, Extended Data and Supplementary ...
These assays provide a means of investigating the physiological role(s) of in normal .doi:10.1385/1-59259-828-5:137Eva KirstenErnest KunJerome MendeleyevCharles P OrdahlMethods Mol BiolMethods in Molecular BiologyKirsten, E., E. Kun, J. Mendeleyev & C. P. Ordahl: Activity assays for poly-...
initiators of protein complex assembly at the site of carrier biogenesis, through the recruitment of specific protein adaptors. These details are predicted to give researchers unprecedented control over membrane traffic, and tools to design the means to alter traffic in ways that will be beneficial ...
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It would be a means for the cell to exert regulation at the translational level. Compared with the promoter region of mammalian PARP-1s, the regulatory region of PARP-2 is very different. PARP-1 does not share its promoter with any other gene, and its organization is typical of that of ...
Jack Cincotta, M.S. HHC, is a board-certified holistic health practitioner who helps individuals achieve optimal mental health through natural means.
Plasmids Flag-HuR, GST and GST-HuR were kindly provided by Dr. Myriam Gorospe (Laboratory of Cellular and Molecular Biology; National Institute on Aging, National Institutes of Health, USA). Plasmid GFP-HuR was provided by Dr. Imed-Eddine Gallouzi (Department of Biochemistry, Division of Crit...
In response to the diversity of roles played by the Ub system in mediating innate immune response, xenophagy, and cellular trafficking, pathogens have evolved a variety of means to confront and even manipulate the Ub system of their eukaryotic hosts25. Previous studies have shown an extensive inte...
(unpaired) was used for significance analysis. A p value less than 0.05 was considered significant. Two WT and two ADPGK KO cell lines were used for each experiment and their respective means (represented as WT and KO) were taken for final data analysis and representation after three ...