In fact, some of the described compounds have been selected for advanced clinical development, meaning that they are promising anticancer drugs candidates. However, most in vitro studies do not show the error associated with IC50 value and there are few molecular docking studies with PARP1. It ...
subtilis was due to a change in the intracellular pH caused by the passage across the cell membrane of these weak organic acids when incubated with B. subtilis at pH values near the pK. More experiments are needed to determine the biological meaning of these in vitro findings....
In the present report, we have studied the specificity of the response to different inducers of apoptosis of PARP null cells and the biological meaning of PARP cleavage during apoptosis. To that purpose, we generated a mutant of PARP in which the specific caspase-3 cleavage site 211DEVD214 ha...
However, the research area is very active with an increasing understanding of PDT-related cell biology, photophysics and significant progress in molecular targeting of disease. Monoclonal antibody therapy is maturing and the next wave of antibody therapies includes antibody-drug conjugates (ADCs), which...