Fibrillar collagen COL6α3 in adipose tissue has been associated with obesity, inflammation, insulin resistance and cancer. We here aimed to identify novel transcriptional regulators ofCOL6A3expression. Based on a transcriptome dataset of adipose tissue, we identified strong correlations for 56 genes ...
Macrophages and dendritic cells (DCs) are well equipped to sense environmental cues and play dominant roles in tissue homeostasis and inflammation. Macrophages comprise the most abundant leukocyte population in the adipose stromal fraction, and their number increases with increasing adiposity in both mice...
The major WAT depots are classified according to their anatomic location as either subcutaneous adipose tissue (SAT) or visceral adipose tissue (VAT). Adipocytes, as the most dominant component of WAT, are consist of mature adipocytes and adipose stem and progenitor cells (ASPCs), which are the...
Adipose tissue-resident regulatory T cells: Phenotypic specialization, functions and therapeutic potential Cipolletta D.Adipose tissue-resident regulatory T cells:phenotypic specialization,functions and therapeutic potential[J].Immunology,2014,142(4):517-525... Cipolletta - 《Immunology An Official Journal...
Adipose tissue is a specialized connective tissue that is comprised of lipid-filled cells (adipocytes) contained within a collagen framework. From: Physical Medicine and Rehabilitation Clinics of North America, 2007 About this pageSet alert Also in subject areas: Agricultural and Biological Sciences Ear...
The invention provides compositions and methods for the use of adipose tissue-derived stromal cells for the treatment and repair of any ocular-associated tissue defect, including but not limited to those secondary to trauma, metabolic disease, inborn errors, or surgery. The adipose tissue-derived st...
Use of cells isolated from the white adipose tissue, extra - marrow depression, selected from the group consisting of the vascular stroma - and a - population of the said fraction of the vascular stroma - consisting of adherent cells, for the preparation of a medicinal product to prevent - ...
White adipose tissue (WAT) and brown adipose tissue (BAT) are tasked with disparate functions. BAT is a thermogenic tissue comprised of multilocular cells, responsible for heat generation and regulation. The composition of the BAT cell is well equipped for this function due to significant ...
Treg cellsVisceral adipose tissue (VAT) is a primary site for storage of excess energy, but it also serves as an important endocrine organ that impacts organismal metabolism. Chronic, low-grade inflammation of VAT, and eventually systemically, is one of the major drivers of obesity-associated ...
Normaladipose tissuecells are found in fragments or clusters in smears showing large fat cells with abundant univacuolated cytoplasm and small dark regular nuclei. In the larger fragments a discrete network of slender capillaries may be observed. Dissociated fat cells are quite uncommon. The larger...