Diabetes, a group of metabolic disorders, constitutes an important global health problem. Diabetes and its complications place a heavy financial strain on both patients and the global healthcare establishment. The lack of effective treatments contributes
In recent years, there have been experiments using mesenchymal stem cells (MSCs) from different sources to treat diabetes. The early focus was on bone marrow-derived MSCs (BM-MSCs), which contain various types of stem cells including hematopoietic stem cells, mesenchymal stem cells, and endothelia...
chemokines, matrix metalloproteinases, and other components of the SASP. The SASP fosters the senescence of neighboring cells and establishes a tissue microenvironment through autocrine and paracrine signaling. The composition and levels of the SASP vary based on the duration of senescence, senescence-ind...
Epithelial cells are specialized cell types that play a crucial role in maintaining the balance of the immune response in the intestines. They interact with mucus and microbiota to promote either tolerance or immunity. While defects in individual epithelial cell types can contribute to inflammation, ...
This appears to be due in large part to differences in technique during tissue harvest, processing, and reimplantation, which result in impairment of the graft healing process. Adipose-derived stem and regenerative cells (ADRCs) contain several different types of cell, including adipose-derived ...
B cell depletion is the standard of care, with an approximately 60% success rate.2 Monoclonal PTLD can form a disseminated malignant lymphoma. Other EBV+ hematological neoplasias include Burkitt’s lymphoma, Hodgkin’s disease, and diffuse large B cell lymphoma (DLBCL).2,6, 7, 8 Additionally...
Following an ischemic injury to the brain, the induction of angiogenesis is critical to neurological recovery. The angiogenic benefits of mesenchymal stem cells (MSCs) have been attributed at least in part to the actions of extracellular vesicles (EVs) t
Multiprotein complexes that contain a member of the NOD-like receptor family, adaptor proteins and the protease caspase 1. These complexes regulate the catalytic processing and secretion of pro-inflammatory cytokines, including interleukin-1β (IL-1β) and IL-18. Reactive oxygen species (ROS). Ch...
Since human adipose tissue is ubiquitous and easily obtained in large quantities using a minimally invasive procedure, the use of autologous ASCs is promising for both regenerative medicine and organs damaged by injury and disease, leading to a rapidly increasing field of research. ASCs are ...
Most of the methods used to isolate ADSCs contain a collagenase digestion step, but the type of collagenase and time of sample digestion vary among studies and these differences could have an impact on the cell properties and thus in result comparison. To overcome this obstacle, we propose a ...